Oral and Maxillofacial Surgical Ward Medical Center, The Affiliated Stomatological Hospital of Soochow University, Suzhou Stomatological Hospital, Suzhou 215000, China.
Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Biomed Res Int. 2021 Jan 28;2021:2615059. doi: 10.1155/2021/2615059. eCollection 2021.
To investigate the correlation between clinical manifestation and neutrophil-lymphocyte ratio, C-reactive protein (CRP), and interleukin-6 (IL-6) in the patients with severe and extremely severe oral and maxillofacial space infection (OMSI).
In this retrospective study, we included 18 patients with severe and extremely severe OMSI from November 2012 to October 2018. Pearson or Spearman correlation coefficients were calculated to measure the association between the number of complications and locations and the number and percentage of lymphocyte, leukocyte, neutrophil, eosinophil, basophil, monocyte, CRP, and IL-6. A multivariable regression model was used to predict the number of complications and locations from these measures.
IL-6 was positively correlated with neutrophil-lymphocyte ratio ( = 0.773, = 0.005), percentage of neutrophil ( = 0.927, = 0.001), and the number of neutrophil ( = 0.627, = 0.039). It was negatively correlated with percentage of monocyte ( = -0.773, = 0.005). CRP was positively correlated with neutrophil-lymphocyte ratio ( = 0.556, = 0.020) and percentage of neutrophil ( = 0.515, = 0.035). It was negatively correlated with the number of lymphocyte ( = -0.517, = 0.017), percentage of lymphocyte ( = -0.578, = 0.015), number of eosinophil ( = -0.560, = 0.020), percentage of eosinophil ( = -0.504, = 0.039), number of basophil ( = -0.504, = 0.039), and percentage of basophil ( = -0.548, = 0.023). The number of the involved organs was positively correlated with neutrophil-lymphocyte ratio ( = 0.511, = 0.030). The number of complications was positively correlated with the percentage of neutrophils ( = 0.738, = 0.001), the neutrophil-lymphocyte ratio ( = 0.576, = 0.012), IL-6 ( = 0.907, = 0.001), and CRP ( = 0.599, = 0.011). Multivariable regression analysis showed that the neutrophil-lymphocyte ratio ( = 0.080) was a significant predictor of the number of the involved organs and the neutrophil-lymphocyte ratio ( = 0.099). In addition, IL-6 ( = 0.002) was a significant predictor of the number of complications.
The neutrophil-lymphocyte ratio and IL-6 contributed to the assessment of general condition in severe and profound OMSI patients. These parameters can be used as predictors to evaluate the severity of OMSI.
探讨中性粒细胞-淋巴细胞比值、C 反应蛋白（CRP）和白细胞介素 6（IL-6）与严重和极严重口腔颌面部间隙感染（OMSI）患者临床表现的相关性。
本回顾性研究纳入了 2012 年 11 月至 2018 年 10 月间 18 例严重和极严重 OMSI 患者。采用 Pearson 或 Spearman 相关系数来衡量并发症的数量和部位与淋巴细胞、白细胞、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、单核细胞、CRP 和 IL-6 的数量和百分比之间的相关性。采用多元回归模型从这些指标预测并发症的数量和部位。
IL-6 与中性粒细胞-淋巴细胞比值（ = 0.773， = 0.005）、中性粒细胞百分比（ = 0.927， = 0.001）和中性粒细胞数量（ = 0.627， = 0.039）呈正相关，与单核细胞百分比（ = -0.773， = 0.005）呈负相关。CRP 与中性粒细胞-淋巴细胞比值（ = 0.556， = 0.020）和中性粒细胞百分比（ = 0.515， = 0.035）呈正相关，与淋巴细胞数量（ = -0.517， = 0.017）、淋巴细胞百分比（ = -0.578， = 0.015）、嗜酸性粒细胞数量（ = -0.560， = 0.020）、嗜酸性粒细胞百分比（ = -0.504， = 0.039）、嗜碱性粒细胞数量（ = -0.504， = 0.039）和嗜碱性粒细胞百分比（ = -0.548， = 0.023）呈负相关。累及器官数量与中性粒细胞-淋巴细胞比值（ = 0.511， = 0.030）呈正相关。并发症数量与中性粒细胞百分比（ = 0.738， = 0.001）、中性粒细胞-淋巴细胞比值（ = 0.576， = 0.012）、IL-6（ = 0.907， = 0.001）和 CRP（ = 0.599， = 0.011）呈正相关。多变量回归分析显示，中性粒细胞-淋巴细胞比值（ = 0.080）是累及器官数量的显著预测因子，中性粒细胞-淋巴细胞比值（ = 0.099）是并发症数量的显著预测因子。此外，IL-6（ = 0.002）是并发症数量的显著预测因子。
中性粒细胞-淋巴细胞比值和 IL-6 有助于评估严重和极严重 OMSI 患者的一般情况。这些参数可作为评估 OMSI 严重程度的预测因子。
