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aYChr-DB:古代人类Y染色体单倍群数据库。

aYChr-DB: a database of ancient human Y haplogroups.

作者信息

Freeman Laurence, Brimacombe Conrad Stephen, Elhaik Eran

机构信息

University of Sheffield, Department of Animal and Plant Sciences, Sheffield S10 2TN, UK.

出版信息

NAR Genom Bioinform. 2020 Oct 9;2(4):lqaa081. doi: 10.1093/nargab/lqaa081. eCollection 2020 Dec.

Abstract

Ancient Y-Chromosomal DNA is an invaluable tool for dating and discerning the origins of migration routes and demographic processes that occurred thousands of years ago. Driven by the adoption of high-throughput sequencing and capture enrichment methods in paleogenomics, the number of published ancient genomes has nearly quadrupled within the last three years (2018-2020). Whereas ancient mtDNA haplogroup repositories are available, no similar resource exists for ancient Y-Chromosomal haplogroups. Here, we present aYChr-DB-a comprehensive collection of 1797 ancient Eurasian human Y-Chromosome haplogroups ranging from 44 930 BC to 1945 AD. We include descriptors of age, location, genomic coverage and associated archaeological cultures. We also produced a visualization of ancient Y haplogroup distribution over time. The aYChr-DB database is a valuable resource for population genomic and paleogenomic studies.

摘要

古代Y染色体DNA是一种非常珍贵的工具,可用于确定数千年前迁徙路线和人口过程的年代并辨别其起源。在古基因组学中高通量测序和捕获富集方法的推动下,过去三年(2018 - 2020年)已发表的古代基因组数量几乎增加了两倍。虽然有古代线粒体DNA单倍群库,但古代Y染色体单倍群却没有类似的资源。在此,我们展示了aYChr-DB——一个包含1797个古代欧亚人类Y染色体单倍群的综合集合,时间跨度从公元前44930年到公元1945年。我们纳入了年龄、地点、基因组覆盖范围和相关考古文化的描述。我们还制作了古代Y单倍群随时间分布的可视化图表。aYChr-DB数据库是群体基因组学和古基因组学研究的宝贵资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ae/7671346/5eca366ff3fa/lqaa081fig1.jpg

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