Professor Philipe de Souto Barreto, Gérontopôle de Toulouse, Institut du Vieillissement, 37 Allées Jules Guesde, F-31000 Toulouse, France, Phone: (+33) 561 145 636, Fax: (+33) 561 145 640, e-mail:
J Frailty Aging. 2021;10(2):86-93. doi: 10.14283/jfa.2020.18.
Aging is the most important risk factor for the onset of several chronic diseases and functional decline. Understanding the interplays between biological aging and the biology of diseases and functional loss as well as integrating a function-centered approach to the care pathway of older adults are crucial steps towards the elaboration of preventive strategies (both pharmacological and non-pharmacological) against the onset and severity of burdensome chronic conditions during aging. In order to tackle these two crucial challenges, ie, how both the manipulation of biological aging and the implementation of a function-centered care pathway (the Integrated Care for Older People (ICOPE) model of the World Health Organization) may contribute to the trajectories of healthy aging, a new initiative on Gerosciences was built: the INSPIRE research program. The present article describes the scientific background on which the foundations of the INSPIRE program have been constructed and provides the general lines of this initiative that involves researchers from basic and translational science, clinical gerontology, geriatrics and primary care, and public health.
衰老是多种慢性疾病和功能下降的最重要危险因素。了解生物衰老与疾病生物学和功能丧失之间的相互作用，以及将以功能为中心的方法整合到老年人的护理途径中，是制定针对衰老过程中出现和加重的负担性慢性疾病的预防策略（包括药理学和非药理学策略）的关键步骤。为了应对这两个关键挑战，即生物衰老的干预和以功能为中心的护理途径的实施（世界卫生组织的老年人综合关怀（ICOPE）模式）如何影响健康衰老的轨迹，我们发起了一项关于老年医学的新倡议：INSPIRE 研究计划。本文描述了 INSPIRE 计划所依据的科学背景，并提供了这项涉及基础和转化科学、临床老年医学、老年病学和初级保健以及公共卫生领域的研究人员的倡议的总体思路。
