Soules M R, Clifton D K, Steiner R A, Cohen N L, Bremner W J
Department of Obstetrics and Gynecology, University of Washington, Seattle.
Obstet Gynecol. 1988 May;71(5):659-66.
Fourteen normal volunteers were studied during one menstrual cycle. Follicular development, the luteinizing hormone (LH) surge, and the relationship between LH and progesterone secretion in the luteal phase were studied to determine the factors that control corpus luteum function. Follicular development was assessed by measuring follicle size and daily estradiol (E2) levels; the LH surge was quantified by determining the area under the curve. Although there was a significant positive correlation between mean follicle diameter and E2, these same parameters did not correlate with postovulatory progesterone secretion; nor did the LH surge correlate with progesterone secretion. A decrease in LH pulse frequency occurred in moving from the follicular to the luteal phase. There was a trend toward an increase in the late luteal LH pulse frequency compared with the midluteal phase, but this was not significant. Progesterone was secreted in an intermittent (pulsatile) fashion in the midluteal and late luteal phases. The general decrease in progesterone in the latter days of the menstrual cycle appears to be due to a decrease in the progesterone pulse amplitude. A significant correlation between LH and progesterone was present when the data were "smoothed"; however, there was not a significant synchrony for LH and progesterone pulses for most of the subjects when the initial data were analyzed by objective criteria. Progesterone secretion in the luteal phase is quite complex and leads to highly variable serum levels of progesterone when samples are obtained at random from normal women.
对14名正常志愿者进行了一个月经周期的研究。研究了卵泡发育、促黄体生成素（LH）峰以及黄体期LH与孕酮分泌之间的关系，以确定控制黄体功能的因素。通过测量卵泡大小和每日雌二醇（E2）水平来评估卵泡发育；通过测定曲线下面积对LH峰进行量化。虽然平均卵泡直径与E2之间存在显著正相关，但这些参数与排卵后孕酮分泌无关；LH峰与孕酮分泌也无相关性。从卵泡期到黄体期，LH脉冲频率降低。与黄体中期相比，黄体后期LH脉冲频率有增加趋势，但不显著。孕酮在黄体中期和后期以间歇性（脉冲式）方式分泌。月经周期后期孕酮的普遍下降似乎是由于孕酮脉冲幅度降低。对数据进行“平滑处理”时，LH与孕酮之间存在显著相关性；然而，当根据客观标准分析初始数据时，大多数受试者的LH和孕酮脉冲没有显著同步性。黄体期孕酮分泌非常复杂，当从正常女性中随机采集样本时，会导致血清孕酮水平高度可变。
