Villar J, Kestler E, Castillo P, Juarez A, Menendez R, Solomons N W
Prevention Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland.
Obstet Gynecol. 1988 May;71(5):697-700.
Loss of intestinal lactase activity among adults could theoretically limit milk consumption and hence dietary availability of calcium during pregnancy. The present study sought to define, using breath hydrogen (H2) production as an index of incomplete carbohydrate absorption, the prevalence during pregnancy of lactose maldigestion of 360 mL of milk (18 g of lactose), and to determine whether lactose digestion improved as pregnancy advanced. The prevalence of lactose maldigestion among 114 pregnant women tested before the 15th week of gestation was 54%. By term, 44% of those originally classified as maldigesters had become digesters. There was a significant reduction in the four-hour sum of the changes in breath H2 concentration from the period before 15 weeks (116.6 +/- 9.6 ppm) to the time after 36 weeks (54.4 +/- 7.3 ppm; P less than .01). This apparent adaptive improvement in intestinal handling of milk lactose during gestation has implications for calcium intake and absorption.
成年人肠道乳糖酶活性丧失理论上可能会限制牛奶摄入量，进而影响孕期饮食中钙的可利用性。本研究旨在以呼出气中氢气（H2）生成量作为碳水化合物吸收不完全的指标，确定孕期乳糖消化不良（360毫升牛奶，含18克乳糖）的发生率，并确定乳糖消化是否随着孕期进展而改善。在妊娠第15周前接受检测的114名孕妇中，乳糖消化不良的发生率为54%。到足月时，最初被归类为消化不良的孕妇中有44%变成了消化良好者。从妊娠15周前到36周后，呼出气中H2浓度变化的四小时总和显著降低（从116.6±9.6 ppm降至54.4±7.3 ppm；P<0.01）。孕期肠道对牛奶乳糖处理的这种明显适应性改善对钙的摄入和吸收具有重要意义。
