Szilagyi Andrew, Malolepszy Paula, Yesovitch Samara, Vinokuroff Christina, Nathwani Usha, Cohen Albert, Xue Xiaoqing
Division of Gastroenterology, Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Dig Dis Sci. 2007 Nov;52(11):2999-3004. doi: 10.1007/s10620-006-9652-9. Epub 2007 Mar 15.
Fructose malabsorption is linked to gastrointestinal and other unusual symptoms. Polymers of fructose are also recognized prebiotics. While some prebiotics can self-adapt when consumed regularly (resulting in decreased breath hydrogen and symptoms), we wondered whether self-adaptation occurs with basic fructose. We evaluated 90 subjects (61 females). Each completed a diet questionnaire and underwent a fructose challenge. Breath hydrogen and quantified symptom scores were recorded. Group comparisons for sum of breath hydrogen and total symptom scores were evaluated with the Mann-Whitney U test. Spearman's correlation coefficient and chi(2) or Fisher's exact test were used as appropriate. Malabsorption occurred in 29 patients (32.2%) and low-grade symptoms without malabsorption in 30 (33%). Women complained of symptoms more frequently (p = 0.04) and exhibited more fructose malabsorption (p = 0.0527). Breath hydrogen correlated with symptoms (r = 0.516, p = 0.0037). Adaptation with increasing pretest fructose intake was absent. We conclude that gender may influence fructose malabsorption and there is no adaptation to regular consumption.
果糖吸收不良与胃肠道及其他异常症状有关。果糖聚合物也是公认的益生元。虽然一些益生元在经常食用时可自我适应（导致呼出气氢气减少和症状减轻），但我们想知道基本果糖是否会出现自我适应。我们评估了90名受试者（61名女性）。每个人都完成了一份饮食问卷并接受了果糖激发试验。记录呼出气氢气和量化的症状评分。用曼-惠特尼U检验评估呼出气氢气总和与总症状评分的组间比较。根据情况使用斯皮尔曼相关系数和卡方检验或费舍尔精确检验。29例患者（32.2%）出现吸收不良，30例（33%）出现无吸收不良的轻度症状。女性更频繁地抱怨症状（p = 0.04）且表现出更多的果糖吸收不良（p = 0.0527）。呼出气氢气与症状相关（r = 0.516，p = 0.0037）。未出现随着试验前果糖摄入量增加而产生的适应情况。我们得出结论，性别可能影响果糖吸收不良，且对常规食用不存在适应情况。
