Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.
Romagna Cancer Registry, Section of Ferrara, Local Health Authority Ferrara, Ferrara, Italy.
Clin Exp Dermatol. 2021 Oct;46(7):1285-1289. doi: 10.1111/ced.14599. Epub 2021 May 11.
To assess the impact of socioeconomic status (SES) on the occurrence of skin cancer in the population living in the province of Ferrara, Italy, a retrospective cohort of patients with squamous cell carcinoma (SCC), basal cell carcinoma (BCC) or malignant melanoma (MM), provided by the local cancer registry, was investigated. The SES was expressed through an ecological-based deprivation index. During the 8-year study period (2006-2013, total person-years 2 859 137), 6051 carcinomas (1535 SCCs, 4365 BCCs) and 459 MMs were diagnosed. Both crude and standardized (on the European population) rates and the standardized incidence ratio showed a direct correlation between BCC and SES. Multivariate analysis confirmed these results for BCC and also for MM, while it showed an excess of SCC incidence in the lowest SES subgroup. This study shows, for the first time, to our knowledge, opposite effects of SES on SCC and BCC occurrence. A role of environmental factors conditioned by SES may be hypothesized.
为了评估社会经济地位（SES）对意大利费拉拉省居民皮肤癌发生的影响，对当地癌症登记处提供的鳞状细胞癌（SCC）、基底细胞癌（BCC）或恶性黑色素瘤（MM）患者的回顾性队列进行了研究。SES 通过基于生态的剥夺指数来表示。在 8 年的研究期间（2006-2013 年，总人年数为 2859137），诊断出 6051 例癌症（1535 例 SCC、4365 例 BCC 和 459 例 MM）。未校正和标准化（基于欧洲人口）的比率和标准化发病比均显示 BCC 与 SES 之间存在直接相关性。多变量分析证实了这些结果，不仅适用于 BCC，也适用于 MM，而 SCC 的发病率在 SES 最低的亚组中则过高。这项研究首次表明，SES 对 SCC 和 BCC 发生的影响相反。可以假设 SES 所决定的环境因素起到了一定作用。
