Department of Dermatology, School of Medicine, University of Jordan, Amman, Jordan.
Department of Radiology and Nuclear Medicine, School of Medicine, University of Jordan, Amman, Jordan.
JCO Glob Oncol. 2023 Feb;9:e2200338. doi: 10.1200/GO.22.00338.
Skin cancers are among the commonest cancers worldwide, and the incidence of melanoma and non-melanoma skin cancer (NMSC) continues to rise worldwide. However, there are no comprehensive reports on skin cancer incidence in Jordan during the past two decades. This report investigates the incidence of skin cancers in Jordan, in particular their time trends for the period 2000-2016.
Data on malignant melanomas (MMs), squamous cells carcinomas (SCCs), and basal cell carcinomas (BCCs) were extracted from the Jordan Cancer Registry for the period between 2000 and 2016. Age-specific and overall age-standardized incidence rates (ASIRs) were computed.
Two thousand seventy patients were diagnosed with at least one BCC, 1,364 with SCC, and 258 with MM. ASIRs were 28, 19, and 4 per 100,000 person-years for BCC, SCC, and MM, respectively. The BCC:SCC incidence ratio was 1.47:1. The risk of men developing SCCs was significantly higher than women (relative risks [RRs], 1.311; 95% CI, 1.197 to 1.436), but significantly lower for BCCs (RR, 0.929; 95% CI, 0.877 to 0.984) or melanomas (RR, 0.465; 95% CI, 0.366 to 0.591). Persons older than 60 years were at a significantly higher risk of developing SCCs (RR, 1.225; 95% CI, 1.119 to 1.340) or melanomas (RR, 2.445; 95% CI, 1.925 to 3.104), but at a significantly lower risk of developing BCCs (RR, 0.885; 95% CI, 0.832 to 0.941). The overall incidence rates of SCCs, BCCs, and melanomas increased over the 16-year study period, but this was not statistically significant.
To our knowledge, this is the largest epidemiologic study regarding skin cancers in Jordan and in the Arab world. Despite low incidence rates in this study, rates are higher than reported regional figures. This is likely due to standardized, centralized, and mandatory reporting of skin cancers, including NMSC.
皮肤癌是全球最常见的癌症之一，黑色素瘤和非黑色素瘤皮肤癌（NMSC）的发病率在全球持续上升。然而，在过去的二十年中，约旦并没有关于皮肤癌发病率的综合报告。本报告调查了约旦皮肤癌的发病率，特别是 2000 年至 2016 年期间的时间趋势。
从 2000 年至 2016 年期间，从约旦癌症登记处提取了恶性黑色素瘤（MM）、鳞状细胞癌（SCC）和基底细胞癌（BCC）的数据。计算了特定年龄和总体年龄标准化发病率（ASIR）。
2070 名患者被诊断出患有至少一种 BCC，1364 名患有 SCC，258 名患有 MM。BCC、SCC 和 MM 的 ASIR 分别为 28、19 和 4 每 100,000 人年。BCC：SCC 发病率比为 1.47:1。男性患 SCC 的风险明显高于女性（相对风险 [RR]，1.311；95%置信区间，1.197 至 1.436），但患 BCC（RR，0.929；95%置信区间，0.877 至 0.984）或黑色素瘤（RR，0.465；95%置信区间，0.366 至 0.591）的风险明显较低。年龄大于 60 岁的人患 SCC（RR，1.225；95%置信区间，1.119 至 1.340）或黑色素瘤（RR，2.445；95%置信区间，1.925 至 3.104）的风险显著增加，但患 BCC（RR，0.885；95%置信区间，0.832 至 0.941）的风险显著降低。在 16 年的研究期间，SCC、BCC 和黑色素瘤的总发病率呈上升趋势，但无统计学意义。
据我们所知，这是关于约旦和阿拉伯世界皮肤癌的最大规模的流行病学研究。尽管本研究中的发病率较低，但高于报告的地区数据。这可能是由于皮肤癌（包括 NMSC）的标准化、集中和强制性报告。
