葡萄糖在心脏生理和病理形成中的作用。
The role of glucose in physiological and pathological heart formation.
机构信息
Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Dev Biol. 2021 Jul;475:222-233. doi: 10.1016/j.ydbio.2021.01.020. Epub 2021 Feb 10.
Cells display distinct metabolic characteristics depending on its differentiation stage. The fuel type of the cells serves not only as a source of energy but also as a driver of differentiation. Glucose, the primary nutrient to the cells, is a critical regulator of rapidly growing embryos. This metabolic change is a consequence as well as a cause of changes in genetic program. Disturbance of fetal glucose metabolism such as in diabetic pregnancy is associated with congenital heart disease. In utero hyperglycemia impacts the left-right axis establishment, migration of cardiac neural crest cells, conotruncal formation and mesenchymal formation of the cardiac cushion during early embryogenesis and causes cardiac hypertrophy in late fetal stages. In this review, we focus on the role of glucose in cardiogenesis and the molecular mechanisms underlying heart diseases associated with hyperglycemia.
细胞根据其分化阶段显示出明显的代谢特征。细胞的燃料类型不仅是能量的来源，也是分化的驱动因素。葡萄糖是细胞的主要营养物质，是快速生长胚胎的关键调节剂。这种代谢变化既是遗传程序变化的结果，也是其原因。胎儿葡萄糖代谢紊乱，如糖尿病妊娠，与先天性心脏病有关。宫内高血糖会影响胚胎早期的左右轴建立、心脏神经嵴细胞的迁移、圆锥形成和心垫的间质形成，并导致晚期胎儿心脏肥大。在这篇综述中，我们重点讨论了葡萄糖在心脏发生中的作用以及与高血糖相关的心脏病的分子机制。
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