Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.
J Hosp Infect. 2021 May;111:35-39. doi: 10.1016/j.jhin.2021.02.004. Epub 2021 Feb 10.
The coronavirus disease 2019 pandemic has resulted in high levels of exposure of medical workers to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Hand decontamination is one of the actions recommended to reduce the risk of infection.
Two disinfectants - BIAKŌS antimicrobial skin and wound cleanser (AWC) and AWC2 (Sanara MedTech, Fort Worth, TX, USA) - were tested to determine whether they can inactivate SARS-CoV-2 upon contact or as a coating applied before contact with the virus.
The ability of AWC and AWC2 to inactivate SARS-CoV-2 was tested in liquid and dried form on plastic surfaces and porcine skin.
AWC and AWC2 were effective in reducing the infectious titre of SARS-CoV-2 in liquid form during application and in dried form 4 h after application. Virus on skin was reduced up to 2 log-fold and 3.5 log-fold after treatment with AWC and AWC2, respectively.
Application of AWC and AWC2 to skin reduces the level of SARS-CoV-2 and the risk of infection.
2019 年冠状病毒病大流行导致医务人员大量接触严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）。手部消毒是减少感染风险的建议措施之一。
测试两种消毒剂——比亚科抗菌皮肤和伤口清洁剂（AWC）和 AWC2（美国德克萨斯州沃思堡的 Sanara MedTech），以确定它们在接触时或接触病毒前作为涂层是否能使 SARS-CoV-2 失活。
在塑料表面和猪皮上以液体和干燥形式测试 AWC 和 AWC2 灭活 SARS-CoV-2 的能力。
AWC 和 AWC2 在应用时的液体形式以及应用后 4 小时的干燥形式均能有效降低 SARS-CoV-2 的感染滴度。分别用 AWC 和 AWC2 处理后，皮肤上的病毒减少了 2 个对数倍和 3.5 个对数倍。
将 AWC 和 AWC2 应用于皮肤可降低 SARS-CoV-2 水平和感染风险。
