University of Oulu, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Oulu, Finland.
University of Oulu, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Oulu, Finland.
Peptides. 2021 Apr;138:170507. doi: 10.1016/j.peptides.2021.170507. Epub 2021 Feb 9.
Hypoxia controls metabolism at several levels, e.g., via mitochondrial ATP production, glucose uptake and glycolysis. Hence it is likely that hypoxia also affects the action and/or production of many peptide hormones linked to food intake and appetite control. Many of those are produced in the gastrointestinal tract, endocrine pancreas, adipose tissue, and selective areas in the brain which modulate and concert their actions. However, the complexity of the hypoxia response and the links to peptides/hormones involved in food intake and appetite control in the different organs are not well known. This review summarizes the role of the hypoxia response and its effects on major peptides linked to appetite regulation, nutrition and metabolism.
缺氧在多个水平上控制代谢，例如通过线粒体 ATP 产生、葡萄糖摄取和糖酵解。因此，缺氧很可能也会影响与食物摄入和食欲控制相关的许多肽类激素的作用和/或产生。这些激素中的许多是在胃肠道、内分泌胰腺、脂肪组织和大脑的特定区域产生的，它们调节和协调它们的作用。然而，缺氧反应的复杂性及其与不同器官中涉及食物摄入和食欲控制的肽类/激素的联系尚不清楚。这篇综述总结了缺氧反应及其对与食欲调节、营养和代谢相关的主要肽类的作用。
