Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.
Procter & Gamble International Operations SA Singapore Branch, 70 Biopolis Street, Singapore 138547, Singapore.
Int J Pharm. 2021 Apr 1;598:120370. doi: 10.1016/j.ijpharm.2021.120370. Epub 2021 Feb 10.
Medicine should ideally be personalized as each individual has his/her own unique biological, physical, and medical dispositions. Medicine can be personalized by customizing drug tablets with the specific drug dosages, release durations, and combinations of multiple drugs. This study presents a method for fabricating drug tablets with customizable dosages, durations, and combinations of multiple drugs by using the 3D printing technology. The method focuses on fabricating customizable drug tablets with a very simple structure for delivering the constant release profile due to its importance in treatment (i.e., the drug may produce side effects if too much is released andmay not have therapeutic value is too little is released). The method is simple: it involves first printing a template using the 3D printer and fabricating the drug tablet via the template. The tablets are customized by varying the amount of excipient used, the height of the tablet, and the numberand amount of drugs used. Three different common drugs (i.e., paracetamol, phenylephrine HCl and diphenhydramine HCl) and FDA-approved excipients are studied. The simplicity of the structure of the tablet and method via templating allows the fabrication of these fully customizable drug tablets to be easily performed, low-cost, efficient, and safe for consumption. These features enable the customizable tablets to be made widely accessible to the public; hence, the concept of personalized medicine can be realized.
理想情况下，医学应该是个性化的，因为每个人都有自己独特的生物、物理和医疗倾向。可以通过定制药物片剂来实现个性化治疗，具体方法是调整特定药物的剂量、释放持续时间以及多种药物的组合。本研究提出了一种使用 3D 打印技术制造可定制剂量、持续时间和多种药物组合的药物片剂的方法。该方法侧重于制造具有可定制剂量、持续时间和多种药物组合的药物片剂，其结构非常简单，因为它在治疗中非常重要（例如，如果释放过多，药物可能会产生副作用，如果释放过少，则可能没有治疗价值）。该方法非常简单：首先使用 3D 打印机打印模板，然后通过模板制造药物片剂。通过改变赋形剂的用量、片剂的高度以及使用的药物的数量和剂量来定制片剂。研究了三种常见药物（即对乙酰氨基酚、盐酸苯肾上腺素和盐酸苯海拉明）和 FDA 批准的赋形剂。片剂的结构和通过模板制造的方法非常简单，这使得这些完全可定制药物片剂的制造变得简单、低成本、高效且安全。这些特点使可定制片剂能够广泛普及，从而实现个性化医疗的理念。
