用于个性化医疗的形状可调紫外打印固体药物。

Shape-Tunable UV-Printed Solid Drugs for Personalized Medicine.

作者信息

Darmawan Bobby Aditya, Lee Sang Bong, Nan Minghui, Nguyen Van Du, Park Jong-Oh, Choi Eunpyo

机构信息

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.

出版信息

Polymers (Basel). 2022 Jul 2;14(13):2714. doi: 10.3390/polym14132714.

DOI:10.3390/polym14132714

PMID:35808759

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9269401/

Abstract

Several recent advances have emerged in biotherapy and the development of personal drugs. However, studies exploring effective manufacturing methods of personal drugs remain limited. In this study, solid drugs based on poly(ethylene glycol)diacrylate (PEGDA) hydrogel and doxorubicin were fabricated, and their final geometry was varied through UV-light patterning. The results suggested that the final drug concentration was affected by the geometrical volume as well as the UV-light exposure time. The analysis of PEGDA showed no effect on the surrounding cells, indicating its high biocompatibility. However, with the addition of doxorubicin, it showed an excellent therapeutic effect, indicating that drugs inside the PEGDA structure could be successfully released. This approach enables personal drugs to be fabricated in a simple, fast, and uniform manner, with perfectly tuned geometry.

摘要

生物疗法和个性化药物的开发最近取得了一些进展。然而，探索个性化药物有效制造方法的研究仍然有限。在本研究中，制备了基于聚（乙二醇）二丙烯酸酯（PEGDA）水凝胶和阿霉素的固体药物，并通过紫外光图案化改变其最终几何形状。结果表明，最终药物浓度受几何体积以及紫外光照射时间的影响。对PEGDA的分析表明其对周围细胞无影响，表明其具有高生物相容性。然而，加入阿霉素后，它显示出优异的治疗效果，表明PEGDA结构内的药物可以成功释放。这种方法能够以简单、快速和均匀的方式制造个性化药物，且具有完美调整的几何形状。