Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.
Procter & Gamble International Operations SA Singapore Branch, 70 Biopolis Street, Singapore 138547, Singapore.
J Control Release. 2020 Jun 10;322:42-52. doi: 10.1016/j.jconrel.2020.02.046. Epub 2020 Mar 5.
Personalized medicine should ideally be prescribed to every individual because of the unique characteristics (e.g., biological, physical, and medical) of each individual. It is, however, challenging to provide personalized medicine for the mass population of specific individuals effectively and efficiently. This manuscript describes a method of fabricating fully customizable drug tablets for personalized medicine by the 3D printing technology. This method involves the versatile fabrication of the tablets via the specifically designed 3D printed molds of different shapes and sizes, and an intuitive 1-dimensional release of drug that relates the shape of the drug-containing matrix to the release profile. The customization includes all the aspects of varying dosage, duration, release profiles, and combination of multiple drugs. In particular, it has previously been technically difficult to devise a single platform that fabricates carriers that release drug with any desired type of release profiles. This method of fabricating fully customizable tablets is simple, inexpensive, and efficient. Detailed selection and investigation of the materials ensured that the tablet and the method of fabrication are safe (e.g., biocompatible, FDA-approved ingredients used) and other desirable features (e.g., sustained release and high dosage) are achieved. These desirable characteristics of the method thus allow fully customizable drug tablets to be fabricated efficiently on the spot after the diagnosis of individual patients; at the same time, the method can be made widely accessible to the mass population. Hence, the concept of personalized medicine can truly be realized.
个性化医疗理想上应该针对每个个体开具，因为每个个体都具有独特的特征（例如，生物、物理和医学特征）。然而，有效地、高效地为特定个体的大量人群提供个性化医疗是具有挑战性的。本文描述了一种通过 3D 打印技术制造完全可定制药物片剂以用于个性化医疗的方法。该方法涉及通过特定设计的不同形状和尺寸的 3D 打印模具来实现片剂的多功能制造，以及药物的直观的一维释放，该释放将药物载体的形状与释放曲线联系起来。定制包括不同剂量、持续时间、释放曲线以及多种药物组合的所有方面。特别是，以前在技术上难以设计一个单一的平台来制造具有任何所需释放曲线的药物载体。这种完全可定制片剂的制造方法简单、廉价且高效。对材料的详细选择和研究确保了片剂和制造方法是安全的（例如，使用生物相容性的、经 FDA 批准的成分）并且具有其他理想的特性（例如，持续释放和高剂量）。因此，该方法的这些理想特性允许在对个体患者进行诊断后高效地现场制造完全可定制的药物片剂；同时，该方法可以广泛地普及到大众人群中。因此，个性化医疗的概念可以真正实现。
