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有无早期姑息治疗的临终结局:一项倾向评分匹配的基于人群的癌症队列研究。

End-of-life outcomes with or without early palliative care: a propensity score matched, population-based cancer cohort study.

机构信息

Department of Oncology, McMaster University, Hamilton, Ontario, Canada

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.

出版信息

BMJ Open. 2021 Feb 12;11(2):e041432. doi: 10.1136/bmjopen-2020-041432.

Abstract

OBJECTIVES

To investigate whether cancer decedents who received palliative care early (ie, >6 months before death) and not-early had different risk of using hospital care and supportive home care in the last month of life.

DESIGN/SETTING: We identified a population-based cohort of cancer decedents between 2004 and 2014 in Ontario, Canada using linked administrative data. Analysis occurred between August 2017 to March 2019.

PARTICIPANTS

We propensity-score matched decedents on receiving early or not-early palliative care using billing claims. We created two groups of matched pairs: one that had Resident Assessment Instrument (RAI) home care assessments in the exposure period (Yes-RAI group) and one that did not (No-RAI group) to control for confounders uniquely available in the assessment, such as health instability and pain. The outcomes were the absolute risk difference between matched pairs in receiving hospital care, supportive home care or hospital death.

RESULTS

In the No-RAI group, we identified 36 238 pairs who received early and not-early palliative care. Those in the early palliative care group versus not-early group had a lower absolute risk difference of dying in hospital (-10.0%) and receiving hospital care (-10.4%) and a higher absolute risk difference of receiving supportive home care (23.3%). In the Yes-RAI group, we identified 3586 pairs, where results were similar in magnitude and direction.

CONCLUSIONS

Cancer decedents who received palliative care earlier than 6 months before death compared with those who did not had a lower absolute risk difference of receiving hospital care and dying in hospital, and an increased absolute risk difference of receiving supportive home care in the last month of life.

摘要

目的

调查在生命的最后一个月内,接受早期(即死亡前>6 个月)和非早期姑息治疗的癌症死亡者使用医院护理和家庭支持性护理的风险是否存在差异。

设计/设置:我们使用链接的行政数据,在加拿大安大略省确定了 2004 年至 2014 年间的一组基于人群的癌症死亡者队列。分析于 2017 年 8 月至 2019 年 3 月进行。

参与者

我们使用计费索赔对接受早期或非早期姑息治疗的死者进行倾向评分匹配。我们创建了两组匹配对:一组在暴露期内接受居民评估工具(RAI)家庭护理评估(Yes-RAI 组),一组未接受(No-RAI 组),以控制评估中唯一存在的混杂因素,如健康不稳定和疼痛。结果是接受医院护理、家庭支持性护理或医院死亡的匹配对之间的绝对风险差异。

结果

在 No-RAI 组中,我们确定了 36238 对接受早期和非早期姑息治疗的匹配对。与非早期组相比,早期姑息治疗组的死亡(-10.0%)和接受医院护理(-10.4%)的绝对风险差异较低,而接受家庭支持性护理(23.3%)的绝对风险差异较高。在 Yes-RAI 组中,我们确定了 3586 对,其结果在数量和方向上相似。

结论

与未接受姑息治疗的患者相比,在死亡前 6 个月内接受姑息治疗的癌症死亡者,在生命的最后一个月内接受医院护理和住院治疗的绝对风险差异较低,而接受家庭支持性护理的绝对风险差异较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b80b/7883853/b168c313b8ce/bmjopen-2020-041432f01.jpg

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