The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China.
Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Curr Genet. 2021 Jun;67(3):417-420. doi: 10.1007/s00294-021-01159-2. Epub 2021 Feb 12.
The causes and consequences of aging have always been a concern. In recent studies, changes in the stress response capacity of cells during aging were quantitatively analyzed. It was found that aging was accompanied by a decline in response capacity. When the response capacity decreased to a critical value, which we assumed was the internal noise level, the cell soon died. To survive, the response capacity should be, at minimum, sufficiently strong to resist intracellular noise. Here, we discuss the role of stress response capacity in aging and conjecture that lifespan might be extended by enhancing stress response capacity.
衰老的原因和后果一直是人们关注的焦点。最近的研究对细胞在衰老过程中应激反应能力的变化进行了定量分析。研究发现，衰老伴随着细胞应激反应能力的下降。当反应能力下降到一个临界值时，我们假设这个临界值就是细胞内的噪声水平，细胞很快就会死亡。为了生存，反应能力至少要足够强大，以抵抗细胞内的噪声。在这里，我们讨论了应激反应能力在衰老过程中的作用，并推测通过增强应激反应能力可能延长寿命。
