Department of Maternal-Infant and Urological Sciences, "Sapienza" University or Rome, Policlinico Umberto I Hospital, Rome, Italy.
Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Endocrine. 2021 Jun;72(3):874-881. doi: 10.1007/s12020-021-02631-2. Epub 2021 Feb 12.
To describe the association between daily activity (i.e., daily step counts and accelerometer intensity measures) and serum TT levels in a representative sample of US adults aged 18 years or older.
A retrospective cohort study was carried out utilizing the NHANES (National Health and Nutrition Examination Survey) 2003-2004 cycle. Physical activity was measured with a waist-worn uniaxial accelerometer (AM-7164; ActiGraph) for up to 7 days using a standardized protocol. Using linear and multivariable logistic regression controlling for relevant social, demographic, lifestyle, and comorbidity characteristics, we assessed the association between daily step counts and TT.
A total of 279 subjects with a median age 46 (IQR: 33-56) were included in the analysis. 23.3% of the cohort had a low serum TT level (TT < 350 ng/dl). Compared to men who took <4000 steps per day, men who took >4000 or >8000 steps/day had a lower odd of being hypogonadal (OR 0.14, 95% CI: 0.07-0.49 and 0.08, 95%CI: 0.02-0.44, respectively). While a threshold effect was noted on average, TT increased 7 ng/dL for each additional 1000 steps taken daily (β-estimate: 0.007, 95% CI: 0.002-0.013).
Patients with the lowest daily step counts had higher odds of being hypogonadal. The current work supports a possible association between daily steps, total testosterone, and hypogonadism for men in the US.
描述美国成年人中，日常活动（即每日步数和加速度计强度测量值）与血清 TT 水平之间的关联。
使用 NHANES（国家健康和营养检查调查）2003-2004 周期进行回顾性队列研究。使用标准化方案，通过佩戴在腰部的单轴加速度计（AM-7164；ActiGraph）进行长达 7 天的身体活动测量。通过线性和多变量逻辑回归，控制相关的社会、人口统计学、生活方式和合并症特征，评估每日步数与 TT 之间的关联。
共有 279 名年龄中位数为 46（IQR：33-56）的受试者纳入分析。队列中有 23.3%的人血清 TT 水平较低（TT<350ng/dl）。与每天行走<4000 步的男性相比，每天行走>4000 步或>8000 步的男性患性腺功能减退症的可能性较低（OR 0.14，95%CI：0.07-0.49 和 0.08，95%CI：0.02-0.44）。虽然平均存在阈值效应，但 TT 随着每天多走 1000 步而增加 7ng/dL（β估计值：0.007，95%CI：0.002-0.013）。
每日步数最低的患者患性腺功能减退症的几率更高。目前的工作支持美国男性中日常步数、总睾酮与性腺功能减退症之间可能存在关联。
