Andreev D N, Kucheryavy Yu A, Mayev I V
Evdokimov Moscow State Medical and Dentistry University, Moscow, Russia.
Ilya Hospital, Krasnogorsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(1):26-30. doi: 10.17116/jnevro202112101126.
Systematization of data on the incidence and risk of sleep disorders in patients with functional dyspepsia (FD).
Studies were searched in the electronic databases MEDLINE/PubMed, EMBASE, Cochrane until October 2020. Publications with detailed descriptive statistics (sample size, number of patients with sleep disorders) were selected for the final analysis, allowing the resulting data to be included in the meta-analysis.
The final analysis included 10 studies with 7739 people (2354 patients with FD, 5385 controls). The generalized incidence of sleep disturbances in patients with FD was 53.23% (95% CI: 37.738-68.419). There was significant heterogeneity between the results (<0.0001; I=98.05%). An association was found between FD and sleep disorders (OR 2.884; 95% CI 2.518-3.304; I=28.35%) compared with controls. In patients with epigastric pain syndrome (EPS), the generalized incidence of sleep disorders was 40.6% (95% CI 34.267-47.181; I=0%), with postprandial distress syndrome (PDS) - 51.82% (95% CI 26.479-76.666; I=94.76%), and at the intersection of EPS and PDS - 51.67% (95% CI 23.497-79.270; I=95.34%).
The meta-analysis has demonstrated that sleep disorders are often associated with FD and are observed in about every second patient with this functional gastrointestinal disease. Further research is needed to investigate possible causal relationships between sleep disorders and FD.
对功能性消化不良（FD）患者睡眠障碍的发病率和风险数据进行系统化整理。
在电子数据库MEDLINE/PubMed、EMBASE、Cochrane中检索截至2020年10月的研究。选择具有详细描述性统计数据（样本量、睡眠障碍患者数量）的出版物进行最终分析，以便将所得数据纳入荟萃分析。
最终分析纳入了10项研究，共7739人（2354例FD患者，5385例对照）。FD患者睡眠障碍的总体发病率为53.23%（95%置信区间：37.738 - 68.419）。结果之间存在显著异质性（<0.0001；I = 98.05%）。与对照组相比，发现FD与睡眠障碍之间存在关联（比值比2.884；95%置信区间2.518 - 3.304；I = 28.35%）。在上腹疼痛综合征（EPS）患者中，睡眠障碍的总体发病率为40.6%（95%置信区间34.267 - 47.181；I = 0%），餐后不适综合征（PDS）患者为51.82%（95%置信区间26.479 - 76.666；I = 94.76%），EPS和PDS交叉患者为51.67%（95%置信区间23.497 - 79.270；I = 95.34%）。
荟萃分析表明，睡眠障碍通常与FD相关，在每两名患有这种功能性胃肠疾病的患者中大约就有一人出现。需要进一步研究以调查睡眠障碍与FD之间可能的因果关系。
