Endoscopy Center, Ehime University Hospital, Toon, Ehime, Japan.
Health Services Center, Ehime University, Matsuyama, Ehime, 790-8577, Japan.
Dig Dis Sci. 2022 Aug;67(8):3929-3937. doi: 10.1007/s10620-021-07260-3. Epub 2021 Oct 7.
Evidence regarding the association between sleep disturbance and functional dyspepsia (FD) remains limited in the young population.
This study aimed to investigate the association between sleep disturbance and FD including subgroups among Japanese young people.
Study subjects were 8923 university students. FD was defined according to the Rome III criteria. Subjects with FD were further categorized as having postprandial distress syndrome (PDS) or epigastric pain syndrome (EPS). Subjects completed a self-reported questionnaire assessing self-reported sleep duration, sleep disturbance, difficulty falling asleep, deep sleep disorder, nocturnal awakening, early awakening, and daytime sleepiness.
The prevalence of FD was 1.9%. After adjustment, all types of sleep disturbances were independently positively associated with FD (total sleep disturbance: OR 4.11 [95% CI: 2.89-5.78], difficulty falling asleep: OR 3.97 [95% CI: 2.53-6.01], deep sleep disorder: OR 4.85 [95% CI: 3.06-7.40], nocturnal awakening: OR 4.35 [95% CI: 1.90-8.67], early awakening: OR 4.50 [95% CI: 1.97-8.97], and daytime sleepiness: OR 2.83 [95% CI: 1.25-5.56]). While nocturnal awakening and daytime sleepiness were not associated with EPS, the other types of sleep disturbance were independently positively associated with EPS and PDS. No association between self-reported sleep duration and FD was found.
Sleep disturbance may be independently positively associated with the prevalence of FD among Japanese young people. Nocturnal awakening and daytime sleepiness were not associated with EPS; the other types of sleep disturbance were independently positively associated with EPS and PDS.
关于睡眠障碍与功能性消化不良（FD）之间关联的证据在年轻人中仍然有限。
本研究旨在调查睡眠障碍与 FD 之间的关联，包括日本年轻人中的亚组。
研究对象为 8923 名大学生。FD 根据罗马 III 标准定义。FD 患者进一步分为餐后不适综合征（PDS）或上腹痛综合征（EPS）。受试者完成了一份自我报告问卷，评估了自我报告的睡眠时间、睡眠障碍、入睡困难、深睡眠障碍、夜间觉醒、早醒和白天嗜睡。
FD 的患病率为 1.9%。调整后，所有类型的睡眠障碍均与 FD 独立正相关（总睡眠障碍：OR 4.11[95%CI：2.89-5.78]，入睡困难：OR 3.97[95%CI：2.53-6.01]，深睡眠障碍：OR 4.85[95%CI：3.06-7.40]，夜间觉醒：OR 4.35[95%CI：1.90-8.67]，早醒：OR 4.50[95%CI：1.97-8.97]，白天嗜睡：OR 2.83[95%CI：1.25-5.56]）。虽然夜间觉醒和白天嗜睡与 EPS 无关，但其他类型的睡眠障碍与 EPS 和 PDS 独立正相关。自我报告的睡眠时间与 FD 之间没有关联。
睡眠障碍可能与日本年轻人中 FD 的患病率独立正相关。夜间觉醒和白天嗜睡与 EPS 无关；其他类型的睡眠障碍与 EPS 和 PDS 独立正相关。
