Netyam Rashmikaa, Shashank Singam, Saravanan Chiranjeevee R, Kolanu Nikhil Deep, Karra Nanditha, Narla Sai Jahnu Sree Reddy, Prajjwal Priyadarshi, Marsool Mohammed Dheyaa Marsool, Hussin Omniat Amir
General Medicine, Hampshire Hospitals, NHS Foundation Trust, Basingstoke, UK.
Internal Medicine, Madras Medical College, India.
Ann Med Surg (Lond). 2025 Jul 25;87(9):5936-5944. doi: 10.1097/MS9.0000000000003616. eCollection 2025 Sep.
Functional dyspepsia (FD), a disease of the gastroduodenal tract, is one of the functional gastrointestinal disorders (FGID) characterized by postprandial fullness and epigastric pain not attributed to any underlying organic diseases. Sleep quality refers to individuals' satisfaction with their overall sleep, including sleep initiation, maintenance, duration, and feeling refreshed upon waking. Despite frequent associations between sleep disorders and FGID, comprehensive data on poor sleep quality (PSQ) in FD patients is lacking. Therefore, this study was conducted to investigate the occurrence of PSQ in patients with PSQ.
PubMed, Scopus, and Web of Science were systematically searched to identify relevant literature. All studies reporting PSQ prevalence in FD patients or sufficient data to calculate it were included. Pooled prevalence was calculated for all studies, and an odds ratio was determined for studies with a healthy control group. Meta-regression and subgroup analyses assessed the moderating effects of different variables. Publication bias was examined using funnel plots and Egger's test p-value. The work has been reported in line with AMSTAR (Assessing the methodological quality of systematic reviews) Guidelines.
To the best of our knowledge, this is the first study that pooled the estimate of prevalence of patients with FD with PSQ. Based on 2138 FD patients, the pooled prevalence of poor sleep quality is 57.2% (95% CI: 37%-75.2%), = 98.4%. The asymmetric funnel plot and Egger's test -value indicated a significant publication bias for the pooled prevalence estimate. FD patients are at higher risk for poor sleep, with an odds ratio of 2.39 (95% CI: 1.86-3.06), = 1.73%.
Poor sleep is highly prevalent among FD patients, who are more susceptible to poor sleep than healthy individuals. The findings of the study should be interpreted with caution owing to the high heterogeneity and the publication bias observed for the pooled prevalence. Future research should standardize diagnostic parameters and investigate other confounding factors like anxiety and depression to achieve more accurate estimates.
功能性消化不良（FD）是一种胃十二指肠疾病，属于功能性胃肠病（FGID），其特征为餐后饱胀感和上腹部疼痛，且无任何潜在的器质性疾病。睡眠质量是指个体对其整体睡眠的满意度，包括入睡、维持睡眠、睡眠时间以及醒来后感觉精力充沛的程度。尽管睡眠障碍与功能性胃肠病之间常有关联，但缺乏关于FD患者睡眠质量差（PSQ）的全面数据。因此，本研究旨在调查FD患者中PSQ的发生率。
系统检索PubMed、Scopus和Web of Science以识别相关文献。纳入所有报告FD患者中PSQ患病率或有足够数据计算该患病率的研究。计算所有研究的合并患病率，并为有健康对照组的研究确定比值比。Meta回归和亚组分析评估不同变量的调节作用。使用漏斗图和Egger检验p值检查发表偏倚。本研究已按照AMSTAR（评估系统评价的方法学质量）指南进行报告。
据我们所知，这是第一项汇总FD伴PSQ患者患病率估计值的研究。基于2138例FD患者，睡眠质量差的合并患病率为57.2%（95%CI：37%-75.2%），I² = 98.4%。不对称漏斗图和Egger检验p值表明合并患病率估计存在显著的发表偏倚。FD患者睡眠质量差的风险更高，比值比为2.39（95%CI：1.86-3.06），I² = 1.73%。
睡眠质量差在FD患者中非常普遍，FD患者比健康个体更容易出现睡眠质量差的情况。由于合并患病率存在高度异质性和发表偏倚，本研究结果应谨慎解读。未来的研究应规范诊断参数，并调查焦虑和抑郁等其他混杂因素，以获得更准确的估计。
