Wuestenberghs Fabien, Melchior Chloé, Desprez Charlotte, Leroi Anne-Marie, Netchitailo Marie, Gourcerol Guillaume
Department of Physiology, Rouen University Hospital, UNIROUEN, Normandy University, Rouen, France.
INSERM Unit 1073, UNIROUEN, Normandy University, Rouen, France.
Front Neurosci. 2022 Feb 8;16:829916. doi: 10.3389/fnins.2022.829916. eCollection 2022.
Sleep disturbances are common in patients with functional dyspepsia. Our aim was to assess the relationship between subjective sleep and quality of life and to identify factors associated with impaired sleep in functional dyspepsia.
One thousand two hundred and twenty patients referred for functional gastrointestinal disorders at a single tertiary care center between end 2017 and June 2019 were studied using a self-administered questionnaire. 355 patients with Rome IV-based functional dyspepsia were identified. Sleep was assessed using both the (PSQI) and the (ISI). The severity of dyspeptic symptoms was assessed using the (TSS). Quality of life was assessed by the (GIQLI). Anxiety and depression levels were evaluated using the (HAD) scale.
Among the 355 patients with functional dyspepsia, 66 (18.6%) patients displayed normal sleep quality whereas 289 (81.4%) patients had altered sleep quality. Functional dyspepsia patients with sleep disturbances were older (48.1 ± 15.4 vs. 41.4 ± 16.0, = 0.0009), had decreased quality of life (GIQLI: 75.3 ± 18.5 vs. 92.1 ± 15.4, < 0.0001), greater severity of their symptoms (TSS: 18.9 ± 3.6 vs. 17.2 ± 3.9, = 0.0007), and higher anxiety and depression scores (HADS: 17.7 ± 7.2 vs. 11.9 ± 5.1, < 0.0001). A correlation was found between sleep quality and quality of life [ = -0.43 (95% CI: -0.51 to -0.34), < 0.0001]. Independent factors predicting poor sleep quality were age [OR 1.03 (95% CI = 1.01-1.05), = 0.006], depression level [OR 1.27 (95% CI = 1.16-1.39); < 0.0001], and the severity of dyspeptic symptoms [OR 1.13 (95% CI = 1.04-1.22); = 0.004].
A high prevalence of sleep disturbances was found in patients suffering from functional dyspepsia, with 81% of them having altered sleep quality and 61% having insomnia based on subjective assessment. Altered sleep quality and insomnia were associated with altered quality of life, higher severity of symptoms, and higher anxiety and depression scores in this disorder.
睡眠障碍在功能性消化不良患者中很常见。我们的目的是评估主观睡眠与生活质量之间的关系，并确定与功能性消化不良患者睡眠受损相关的因素。
2017年底至2019年6月期间，在一家三级医疗中心就诊的1220名功能性胃肠疾病患者使用自行填写的问卷进行了研究。确定了355例基于罗马IV标准的功能性消化不良患者。使用匹兹堡睡眠质量指数（PSQI）和失眠严重程度指数（ISI）评估睡眠情况。使用消化不良症状严重程度评分（TSS）评估消化不良症状的严重程度。使用胃肠道生活质量指数（GIQLI）评估生活质量。使用医院焦虑抑郁量表（HAD）评估焦虑和抑郁水平。
在355例功能性消化不良患者中，66例（18.6%）睡眠质量正常，而289例（81.4%）睡眠质量改变。睡眠障碍的功能性消化不良患者年龄较大（48.1±15.4岁 vs. 41.4±16.0岁，P = 0.0009），生活质量下降（GIQLI：75.3±18.5 vs. 92.1±15.4，P < 0.0001），症状严重程度更高（TSS：18.9±3.6 vs. 17.2±3.9，P = 0.0007），焦虑和抑郁评分更高（HADS：17.7±7.2 vs. 11.9±5.1，P < 0.0001）。发现睡眠质量与生活质量之间存在相关性[r = -0.43（95%CI：-0.51至-0.34），P < 0.0001]。预测睡眠质量差的独立因素是年龄[OR 1.03（95%CI = 1.01 - 1.05），P = 0.006]、抑郁水平[OR 1.27（95%CI = 1.16 - 1.39）；P < 0.0001]和消化不良症状的严重程度[OR 1.13（95%CI = 1.04 - 1.22）；P = 0.004]。
在功能性消化不良患者中发现睡眠障碍的患病率很高，根据主观评估，其中81%的患者睡眠质量改变，61%的患者有失眠。在这种疾病中，睡眠质量改变和失眠与生活质量改变、症状严重程度更高以及焦虑和抑郁评分更高有关。
