Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
College of Animal Science, Yangtze University, Jingzhou 434000, China.
J Hazard Mater. 2021 Jul 5;413:125239. doi: 10.1016/j.jhazmat.2021.125239. Epub 2021 Jan 26.
Melatonin (MEL) shows an anti-inflammatory effect and regulates intestinal microbiota communities in animals and humans; Ochratoxin A (OTA) induces liver inflammation through intestinal microbiota. However, it remains to know whether MEL alleviates the liver inflammation induced by OTA. In this study, MEL reversed various adverse effects induced by OTA. MEL recovered the swarming and motility of intestinal microbiota, decreased the accumulation of lipopolysaccharide (LPS), enhanced the tight junction proteins of jejunum and cecum segments; ultimately alleviated OTA-induced liver inflammation in ducks. However, it is worth noting that MEL still had positive effects on the OTA-exposed ducks after antibiotic treatment. These results suggest that both the maintenance of intestinal microbiota homeostasis and intestinal microbiota-independent manner involved the MEL anti-inflammatory function in OTA-induced liver inflammation. MEL represent a promising protective approach for OTA, even other mycotoxins.
褪黑素（MEL）在动物和人类中表现出抗炎作用，并调节肠道微生物群落；赭曲霉毒素 A（OTA）通过肠道微生物群引起肝脏炎症。然而，目前尚不清楚 MEL 是否可以减轻 OTA 引起的肝脏炎症。在这项研究中，MEL 逆转了 OTA 引起的各种不良反应。MEL 恢复了肠道微生物的群集和运动性，减少了脂多糖（LPS）的积累，增强了空肠和盲肠段的紧密连接蛋白；最终减轻了鸭子的 OTA 诱导的肝脏炎症。然而，值得注意的是，即使在抗生素处理后，MEL 对暴露于 OTA 的鸭子仍有积极影响。这些结果表明，MEL 的抗炎功能既涉及维持肠道微生物群落的动态平衡，也涉及肠道微生物群落非依赖性途径，在 OTA 诱导的肝脏炎症中发挥作用。MEL 代表了一种有前途的保护方法，适用于 OTA，甚至其他霉菌毒素。
