Eriksson C J
Adv Exp Med Biol. 1977;85A:319-41. doi: 10.1007/978-1-4899-5181-6_21.
The liver is the primary site for the oxidation of ethanol-derived acetaldehyde (AcH) in the rat. Only a small amount of the total AcH formed in this organ escapes into the rest of the body, but this amount increases with increasing hepatic ethanol concentrations. The bulk of the hepatic AcH output is eliminated extrahepatically, thus drastically changing the AcH level from that initially leaving the liver. Nevertheless, the extrahepatic blood AcH levels can be used as relatively accurate indicators of the corresponding hepatic AcH levels, since they are highly correlated with them. Significant levels of brain AcH occur only at very high arterial blood AcH concentrations.
肝脏是大鼠体内乙醇衍生的乙醛（AcH）氧化的主要部位。在该器官中形成的总AcH中只有少量逸出到身体其他部位，但随着肝脏乙醇浓度的增加，这一量会增加。肝脏AcH输出的大部分在肝外被清除，从而使AcH水平与最初离开肝脏时的水平相比发生了巨大变化。然而，肝外血液中的AcH水平可作为相应肝脏AcH水平的相对准确指标，因为它们与肝脏AcH水平高度相关。只有在非常高的动脉血AcH浓度下，大脑中才会出现显著水平的AcH。
