Grüssner R, Rademacher U, Mentges B, von Bülow M, Grüssner A
Chirurgischen Klinik, Mainz.
Zentralbl Chir. 1988;113(3):174-82.
Fifty-one patients below the age of forty were treated for stomach carcinoma at the Surgical Hospital of Mainz University, between 1970 and 1986. They accounted for 5.2 per cent of all patients with stomach carcinoma. Diagnosis had been delayed under the following characteristic circumstances: The interval between onset of symptoms and diagnosis had been more than a year in 34 per cent of all cases. Fifty per cent of the patients had been originally hospitalised, following false suspicious diagnosis. Primary examination for gastro-intestinal passage produced falsely negative results in 43 per cent. The same falsely negative outcome was recorded from 24 per cent, following gastroscopy, and from twelve per cent, following gastroscopy combined with tissue sampling. The percentage of early stomach carcinomas was twice as high as that recorded from patients over forty. Undifferentiated carcinomas, on the other hand, were predominant in patients below forty, whereas adenocarcinomas were primarily recorded from patients over forty. Curative resection was successful in 55 per cent of the over-forties and 44 per cent of the under-forties. No-recurrence intervals were longer among the over-forties. However, five-year survival rates in Stages I, II, and III were better among the under-forties. Hence, the conclusion has been drawn from these findings that stomach carcinoma prognosis of patients below forty is better than that in higher age groups. This, however, is contradictory to other investigations reported in the literature.
1970年至1986年间,美因茨大学外科医院对51名40岁以下的胃癌患者进行了治疗。他们占所有胃癌患者的5.2%。在以下典型情况下诊断被延误:在所有病例中,34%的患者症状出现与诊断之间的间隔超过一年。50%的患者最初因错误的疑似诊断而住院。胃肠道检查的初次检查结果在43%的病例中呈假阴性。胃镜检查后,24%的病例出现同样的假阴性结果,胃镜检查结合组织采样后,12%的病例出现假阴性结果。早期胃癌的比例是40岁以上患者的两倍。另一方面,40岁以下患者中未分化癌占主导,而40岁以上患者主要为腺癌。40岁以上患者中55%的根治性切除成功,40岁以下患者中44%的根治性切除成功。40岁以上患者的无复发间隔时间更长。然而,40岁以下患者在I、II和III期的五年生存率更高。因此,从这些发现中得出的结论是,40岁以下患者的胃癌预后优于年龄较大的患者群体。然而,这与文献中报道的其他研究结果相矛盾。