Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Key Lab. of Biomass Energy and Material, Jiangsu Province, Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Nanjing 210042, China.
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
J Asian Nat Prod Res. 2022 Feb;24(2):153-162. doi: 10.1080/10286020.2021.1886088. Epub 2021 Feb 15.
Two novel acylated steroidal sapogenins, 3-acetoxy-1, 2, 4, 5, 7-pentahydroxy-spirost-25(27)-en-6-one () and (25S)-3-acetoxy-1, 2, 4, 5, 7-pentahydroxyspirostan-6-one (), together with two known steroidal sapogenins ( and ), were isolated from rhizomes. Their structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. In addition, the antifungal activities of the isolated compounds against and were evaluated. Compound significantly inhibited growth, which was comparable to the positive control (sodium benzoate and carbendazim). Compound showed the highest potency to inhibit growth compared to other compounds.
从根茎中分离得到两种新的酰化甾体皂素，3-乙酰氧基-1,2,4,5,7-五羟基螺甾-25(27)-烯-6-酮()和(25S)-3-乙酰氧基-1,2,4,5,7-五羟基螺甾烷-6-酮()，以及两种已知的甾体皂素()和()。通过核磁共振（NMR）和质谱（MS）数据阐明了它们的结构。此外，还评估了分离得到的化合物对和的抗真菌活性。化合物对生长有显著抑制作用，与阳性对照（苯甲酸钠和多菌灵）相当。与其他化合物相比，化合物对生长的抑制作用最强。
