Institut Pasteur, Biology of Infection Unit, Paris, France; Inserm U1117, Paris, France.
Institut Pasteur, Biology of Infection Unit, Paris, France; Inserm U1117, Paris, France; Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center for Listeria, Paris, France.
Trends Microbiol. 2021 Sep;29(9):811-822. doi: 10.1016/j.tim.2021.01.008. Epub 2021 Feb 11.
Listeria monocytogenes is a foodborne pathogen responsible for listeriosis, an infection that can manifest in humans as bacteremia, meningoencephalitis in immunocompromised patients and the elderly, and fetal-placental infection in pregnant women. Reference strains from this facultative intracellular bacterium have been instrumental in the investigation of basic mechanisms in microbiology, immunology, and cell biology. The integration of bacterial population genomics with environmental, epidemiological, and clinical data allowed the uncovering of new factors involved in the virulence of L. monocytogenes and its adaptation to different environments. This review illustrates how these investigations have led to a better understanding of the bacterium's virulence and the driving forces that shaped it.
李斯特菌是一种食源性病原体，可导致李斯特菌病，这种感染在人类中表现为菌血症、免疫功能低下患者和老年人的脑膜脑炎，以及孕妇的胎儿-胎盘感染。来自这种兼性细胞内细菌的参考菌株在微生物学、免疫学和细胞生物学的基础机制研究中发挥了重要作用。将细菌群体基因组学与环境、流行病学和临床数据相结合，揭示了参与李斯特菌毒力及其适应不同环境的新因素。这篇综述说明了这些研究如何使人们更好地了解细菌的毒力及其形成的驱动力。
