与年龄相关的 EBV 相关淋巴组织增生性疾病伪装为系统性红斑狼疮。
Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus.
机构信息
Department of Endocrinology and Rheumatology, Kurashiki Central Hospital, Japan.
Department of Anatomic Pathology, Kurashiki Central Hospital, Japan.
出版信息
Intern Med. 2021 Aug 1;60(15):2495-2497. doi: 10.2169/internalmedicine.6702-20. Epub 2021 Feb 15.
Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals.
老年人非免疫缺陷相关的 EBV 阳性 B 细胞淋巴增殖性疾病（LPD）。一位 81 岁的老年女性，无任何已知免疫缺陷，出现发热、皮疹、关节炎、血小板减少、胸腔和心包积液、淋巴结病和自身抗体阳性，符合系统性红斑狼疮（SLE）的分类标准。然而，淋巴结活检显示 EBV-LPD，诊断为年龄相关性 EBV-LPD。在年轻人中，EBV 感染是 SLE 的主要鉴别诊断，但据我们所知，这是首例年龄相关性 EBV-LPD 模仿 SLE 的报道。因此，即使是在老年人中，我们也应该考虑 EBV 相关疾病作为 SLE 的鉴别诊断。
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