Kriska A M, Sandler R B, Cauley J A, LaPorte R E, Hom D L, Pambianco G
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA.
Am J Epidemiol. 1988 May;127(5):1053-63. doi: 10.1093/oxfordjournals.aje.a114881.
The aim of the present research was to determine the association between historical physical activity and baseline bone measurements in a group of 223 postmenopausal women participating in a clinical trial in Pittsburgh, Pennsylvania, from 1981 to 1986 by evaluating the effect of moderate physical activity on bone loss. Historical physical activity was assessed by a survey which divided the life span into four time periods (14-21, 22-34, 35-50, and 50+ years) and inquired about participation in leisure time physical activities for each period. From the responses, kilocalories of energy expenditure were calculated. Cortical bone density and area were measured in the radius with a computerized tomography scanner. The historical physical activity survey was administered a second time two to three months after the initial test to a 10% random sample of the women in order to determine the test-retest reliability of the instrument. Since the measurements of historical physical activity proved to be reliable, estimates of kilocalories determined for the entire population of women were correlated with bone area and density. A significant relation was found to exist between historical physical activity and dimensions of adult bone, particularly bone area. This association remained significant after adjustment for potential confounding variables and seemed to be strongest in the earlier age periods. To the authors' knowledge, this is the first report of a significant association between historical physical activity and bone.
本研究的目的是通过评估适度体育活动对骨质流失的影响，确定1981年至1986年期间在宾夕法尼亚州匹兹堡参加一项临床试验的223名绝经后妇女的既往体育活动与基线骨测量值之间的关联。既往体育活动通过一项调查进行评估，该调查将寿命分为四个时间段（14 - 21岁、22 - 34岁、35 - 50岁和50岁以上），并询问每个时间段参与休闲体育活动的情况。根据回答计算能量消耗的千卡数。使用计算机断层扫描仪测量桡骨的皮质骨密度和面积。在初次测试后的两到三个月，对10%的女性随机样本再次进行既往体育活动调查，以确定该工具的重测信度。由于既往体育活动的测量结果被证明是可靠的，因此为全体女性确定的千卡估计值与骨面积和密度相关。研究发现既往体育活动与成人骨骼尺寸，尤其是骨面积之间存在显著关系。在对潜在混杂变量进行调整后，这种关联仍然显著，并且在较早年龄段似乎最为强烈。据作者所知，这是既往体育活动与骨骼之间存在显著关联的首次报告。
