Department of Kinesiology and Public Health, California Polytechnic State University San Luis Obispo, San Luis Obispo, California.
Department of Population Health Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.
Cancer Epidemiol Biomarkers Prev. 2023 Jan 9;32(1):30-36. doi: 10.1158/1055-9965.EPI-22-0768.
Moderate-vigorous physical activity (MVPA) reduces colon cancer risk; however, it is unclear how the timing of MVPA throughout the adult life course impacts colon cancer risk. We evaluated whether maintenance and changes in MVPA levels over time are associated with colon cancer risk.
We assessed 293,198 adults ages 50 to 71 years in the NIH-AARP Diet and Health Study. Participants completed baseline health and physical activity questionnaires between 1995 and 1997 and were followed through 2011, (average follow-up of 13.1 years). There were 5,072 colon cancer cases over the study period. Using latent class trajectory models, we identified seven distinct MVPA trajectories across the adult life course (15-18, 19-29, 30-35, and past 10-years) and ran Cox proportional hazards regression models.
Compared with those who maintained low MVPA levels, those who maintained high and moderate levels of MVPA had a lower risk of colon cancer [HR, 0.85; confidence interval (CI), 0.78-0.93; HR = 0.87; CI, 0.76-1.00)], and those who increased MVPA levels early and later during adulthood had a lower colon cancer risk (HR, 0.90; CI, 0.80-1.01) and (HR, 0.92; CI, 0.80-1.06), respectively. Those who decreased MVPA early in adulthood had an increased risk of colon cancer (HR, 1.12; CI, 1.02-1.23). These associations were stronger in adults ages <65 years at baseline and in men (P < 0.001).
Consistent participation in MVPA throughout life may reduce colon cancer risk.
These findings emphasize that engaging in MVPA throughout adulthood lowers risk of colon cancer.
适度剧烈的身体活动（MVPA）可降低结肠癌风险；然而，目前尚不清楚整个成年期 MVPA 的时间安排如何影响结肠癌风险。我们评估了随着时间的推移，MVPA 水平的维持和变化是否与结肠癌风险相关。
我们评估了 NIH-AARP 饮食与健康研究中年龄在 50 至 71 岁的 293198 名成年人。参与者在 1995 年至 1997 年间完成了基线健康和身体活动问卷，并在研究期间（平均随访 13.1 年）进行了随访。在研究期间共发生了 5072 例结肠癌病例。使用潜在类别轨迹模型，我们确定了成年期的七种不同 MVPA 轨迹（15-18 岁、19-29 岁、30-35 岁和过去 10 年），并运行了 Cox 比例风险回归模型。
与那些维持低 MVPA 水平的人相比，那些维持高和中等 MVPA 水平的人患结肠癌的风险较低[风险比（HR），0.85；置信区间（CI），0.78-0.93；HR = 0.87；CI，0.76-1.00]，那些在成年早期和晚期增加 MVPA 水平的人患结肠癌的风险较低（HR，0.90；CI，0.80-1.01）和（HR，0.92；CI，0.80-1.06）。那些在成年早期减少 MVPA 水平的人结肠癌风险增加（HR，1.12；CI，1.02-1.23）。这些关联在基线年龄<65 岁的成年人和男性中更强（P < 0.001）。
在整个成年期持续参与 MVPA 可能会降低结肠癌的风险。
这些发现强调了在成年期进行 MVPA 可降低结肠癌的风险。
