脂肪细胞通过调节脂质代谢来控制脂肪组织免疫，是其“调控塔”。
Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism.
机构信息
National Creative Research Initiatives Center for Adipocyte Structure and Function, Seoul National University, Seoul, South Korea.
Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.
出版信息
Front Immunol. 2021 Jan 28;11:598566. doi: 10.3389/fimmu.2020.598566. eCollection 2020.
Accumulating evidence reveals that adipose tissue is an immunologically active organ that exerts multiple impacts on the regulation of systemic energy metabolism. Adipose tissue immunity is modulated by the interactions between adipocytes and various immune cells. Nevertheless, the underlying mechanisms that control inter-cellular interactions between adipocytes and immune cells in adipose tissue have not been thoroughly elucidated. Recently, it has been demonstrated that adipocytes utilize lipid metabolites as a key mediator to initiate and mediate diverse adipose tissue immune responses. Adipocytes present lipid antigens and secrete lipid metabolites to determine adipose immune tones. In addition, the interactions between adipocytes and adipose immune cells are engaged in the control of adipocyte fate and functions upon metabolic stimuli. In this review, we discuss an integrated view of how adipocytes communicate with adipose immune cells using lipid metabolites. Also, we briefly discuss the newly discovered roles of adipose stem cells in the regulation of adipose tissue immunity.
越来越多的证据表明，脂肪组织是一个具有免疫活性的器官，它对全身能量代谢的调节有多种影响。脂肪组织免疫受脂肪细胞与各种免疫细胞之间相互作用的调节。然而，控制脂肪组织中脂肪细胞与免疫细胞之间细胞间相互作用的潜在机制尚未得到充分阐明。最近，已经证明脂肪细胞利用脂质代谢物作为启动和介导多种脂肪组织免疫反应的关键介质。脂肪细胞呈现脂质抗原并分泌脂质代谢物来决定脂肪免疫的基调。此外，脂肪细胞与脂肪免疫细胞之间的相互作用参与了代谢刺激下脂肪细胞命运和功能的控制。在这篇综述中，我们讨论了脂肪细胞如何利用脂质代谢物与脂肪免疫细胞进行通讯的综合观点。此外，我们还简要讨论了脂肪干细胞在调节脂肪组织免疫中的新发现作用。
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