低水平激光治疗对正畸微种植体稳定性的影响：系统评价和荟萃分析。
Effects of low-level laser therapy on the orthodontic mini-implants stability: a systematic review and meta-analysis.
机构信息
Department of Clinical Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Monsenhor Furtado Street, Rodolfo Teófilo, Fortaleza, Ceará, 60430-350, Brazil.
Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Prog Orthod. 2021 Feb 15;22(1):6. doi: 10.1186/s40510-021-00350-y.
OBJECTIVES
The aim of this systematic review and meta-analysis was to assess the effects of low-level laser therapy (LLLT) on the orthodontic mini-implants (OMI) stability.
MATERIALS AND METHODS
An unrestricted electronic database search in PubMed, Science Direct, Embase, Scopus, Web of Science, Cochrane Library, LILACS, Google Scholar, and ClinicalTrials.gov and a hand search were performed up to December 2020. Randomized clinical trials (RCTs) or non-randomized clinical trials (Non-RCTs) that assessed the effects of LLLT on the OMI stability were included. Data regarding the general information, LLLT characteristics, and outcomes were extracted. The authors performed risk of bias assessment with Cochrane Collaboration's or ROBINS-I tool. Meta-analysis was also conducted.
RESULTS
Five RCTs and one Non-RCT were included and 108 patients were evaluated. The LLLT characteristics presented different wavelength, power, energy density, irradiation time, and protocol duration. Five RCTs had a low risk of selection bias. Two RCTs had a low risk of performance and detection bias. All RCTs had a low risk of attrition bias, reporting bias and other bias. The Non-RCT presented a low risk of bias for all criteria, except for the bias in selection of participants. The meta-analysis revealed that LLLT significantly increased the OMI stability (p < 0.001, Cohen's d = 0.67) and the highest clinical benefit was showed after 1 (p < 0.001, Cohen's d = 0.75), 2 (p < 0.001, Cohen's d = 1.21), and 3 (p < 0.001, Cohen's d = 1.51) months of OMI placement.
CONCLUSIONS
LLLT shows positive effects on the OMI stability.
目的
本系统评价和荟萃分析的目的是评估低水平激光疗法（LLLT）对正畸微种植体（OMI）稳定性的影响。
材料与方法
截至 2020 年 12 月，我们在 PubMed、Science Direct、Embase、Scopus、Web of Science、Cochrane Library、LILACS、Google Scholar 和 ClinicalTrials.gov 上进行了无限制的电子数据库检索，并进行了手工检索。我们纳入了评估 LLLT 对 OMI 稳定性影响的随机临床试验（RCT）或非随机临床试验（Non-RCT）。我们提取了关于一般信息、LLLT 特征和结果的数据。作者使用 Cochrane 协作或 ROBINS-I 工具进行了偏倚风险评估。我们还进行了荟萃分析。
结果
我们纳入了 5 项 RCT 和 1 项 Non-RCT，共评估了 108 名患者。LLLT 的特征包括不同的波长、功率、能量密度、辐照时间和疗程。5 项 RCT 存在选择偏倚的低风险。2 项 RCT 存在实施和检测偏倚的低风险。所有 RCT 均存在失访偏倚、报告偏倚和其他偏倚的低风险。Non-RCT 除参与者选择偏倚外，所有标准的偏倚风险均较低。荟萃分析显示，LLLT 显著增加了 OMI 的稳定性（p < 0.001，Cohen's d = 0.67），在 OMI 放置后 1（p < 0.001，Cohen's d = 0.75）、2（p < 0.001，Cohen's d = 1.21）和 3（p < 0.001，Cohen's d = 1.51）个月时的临床获益最大。
结论
LLLT 对 OMI 的稳定性有积极影响。
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