State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Lasers Med Sci. 2021 Oct;36(8):1557-1566. doi: 10.1007/s10103-021-03281-6. Epub 2021 Mar 4.
The study aimed to assess trials investigating the effect of PBMT on mini-implant stability. Electronic searches of seven databases and manual search were conducted up to May 2020. Randomized controlled trials and controlled clinical trials evaluating the effect of PBMT on mini-implant stability were included. The risks of bias of individual studies were performed using ROB 2.0 and ROBINS-I-tool based on different study design. Meta-analysis was conducted to compare mini-implant stability exposed to PBMT with control ones at different time points after implantation. Among the 518 records initially identified, seven studies were included in this study. Six studies investigated low-level laser therapy (LLLT) and one study evaluated light-emitting diode (LED) therapy. Two studies were eligible for meta-analysis, which showed that LLLT significantly improved mini-implant stability 60 days after initial implantation (MD - 3.01, 95% CI range [- 4.68, - 1.35], p = 0.0004). High energy density of LLLT began to show beneficial effect on mini-implant stability as early as 3 days after implantation, while the significant effect of low energy density displayed later than 30 days after insertion. LED therapy could improve mini-implant stability after 2 months post-insertion. In conclusion, PBMT appears to be beneficial in ameliorating mini-implant stability. High energy density of LLLT might exert more rapid effect than low energy density. More high-quality clinical trials are needed to further demonstrate PBMT' effects on orthodontic mini-implants.
本研究旨在评估探讨光生物调节疗法（PBMT）对微型种植体稳定性影响的试验。通过电子检索了七个数据库，并进行了截至 2020 年 5 月的手工搜索。纳入了评价 PBMT 对微型种植体稳定性影响的随机对照试验和对照临床试验。使用 ROB 2.0 和 ROBINS-I-tool 根据不同的研究设计对单个研究的偏倚风险进行了评估。对不同植入后时间点暴露于 PBMT 和对照组的微型种植体稳定性进行了荟萃分析。在最初确定的 518 条记录中，有 7 项研究纳入了本研究。其中 6 项研究调查了低水平激光疗法（LLLT），1 项研究评估了发光二极管（LED）疗法。有 2 项研究符合荟萃分析的条件，结果表明，LLLT 可显著改善初始植入后 60 天的微型种植体稳定性（MD - 3.01，95%CI 范围[-4.68，-1.35]，p = 0.0004）。高能量密度的 LLLT 早在植入后 3 天就开始对微型种植体稳定性产生有益影响，而低能量密度的显著效果则在插入后 30 天以后才显现。LED 疗法可在植入后 2 个月改善微型种植体稳定性。总之，PBMT 似乎有益于改善微型种植体稳定性。高能量密度的 LLLT 可能比低能量密度更早发挥作用。需要更多高质量的临床试验来进一步证明 PBMT 对正畸微型种植体的效果。
