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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.甲磺酸卡莫司他通过 TMPRSS2 相关蛋白酶抑制 SARS-CoV-2 的激活,其代谢产物 GBPA 发挥抗病毒活性。
EBioMedicine. 2021 Mar;65:103255. doi: 10.1016/j.ebiom.2021.103255. Epub 2021 Mar 4.
2
Can SARS-CoV-2 Accumulate Mutations in the S-Protein to Increase Pathogenicity?严重急性呼吸综合征冠状病毒2(SARS-CoV-2)能否在刺突蛋白(S蛋白)中积累突变以增加致病性?
ACS Pharmacol Transl Sci. 2020 Sep 8;3(5):1023-1026. doi: 10.1021/acsptsci.0c00113. eCollection 2020 Oct 9.
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Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome.从单个细菌人工染色体中拯救 SARS-CoV-2。
mBio. 2020 Sep 25;11(5):e02168-20. doi: 10.1128/mBio.02168-20.
4
Emergence of SARS-CoV-2 through recombination and strong purifying selection.SARS-CoV-2 通过重组和强烈的纯化选择而出现。
Sci Adv. 2020 Jul 1;6(27). doi: 10.1126/sciadv.abb9153. Print 2020 Jul.
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Immunological considerations for COVID-19 vaccine strategies.针对 COVID-19 疫苗策略的免疫学考虑。
Nat Rev Immunol. 2020 Oct;20(10):615-632. doi: 10.1038/s41577-020-00434-6. Epub 2020 Sep 4.
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Origin and cross-species transmission of bat coronaviruses in China.中国蝙蝠冠状病毒的起源与跨物种传播。
Nat Commun. 2020 Aug 25;11(1):4235. doi: 10.1038/s41467-020-17687-3.
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The Origin of COVID-19 and Why It Matters.新冠病毒(COVID-19)的起源及其重要性。
Am J Trop Med Hyg. 2020 Sep;103(3):955-959. doi: 10.4269/ajtmh.20-0849.
8
The biggest mystery: what it will take to trace the coronavirus source.最大的谜团:追踪新冠病毒源头需要付出什么。
Nature. 2020 Jun 5. doi: 10.1038/d41586-020-01541-z.
9
Even covid-19 can't kill the anti-vaccination movement.就连新冠疫情也无法扼杀反疫苗运动。
BMJ. 2020 Jun 4;369:m2184. doi: 10.1136/bmj.m2184.
10
Curbing Misinformation and Disinformation in the COVID-19 Era: A View from Cuba.遏制新冠疫情时代的错误信息和虚假信息:来自古巴的观点。
MEDICC Rev. 2020 Apr;22(2):45-46. doi: 10.37757/MR2020.V22.N2.12.

SARS-CoV-2、Covid-19 与阴谋论的破除。

SARS-CoV-2, Covid-19, and the debunking of conspiracy theories.

机构信息

Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Center for Child Health-PRO, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

出版信息

Rev Med Virol. 2021 Nov;31(6):e2222. doi: 10.1002/rmv.2222. Epub 2021 Feb 14.

DOI:10.1002/rmv.2222
PMID:33586302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7995093/
Abstract

The emergence of a novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has engaged considerable awareness and attention around the world. The associated disease, coronavirus disease 2019 (Covid-19), has now involved virtually all 200 countries. The total number of confirmed cases has been much more than in the two previous outbreaks of human coronaviruses, that is, SARS-CoV and Middle East respiratory syndrome coronavirus. In line with the outbreak escalation, false information about SARS-CoV-2 and its associated disease disseminated globally, particularly through online and social media. Believers in conspiracy theories promote misinformation that the virus is not contagious, is the result of laboratory manipulation or is created to gain profit by distributing new vaccines. The most dangerous effect of this widely disseminated misinformation is it will negatively influence the attitudes and behaviours for preventive measures to contain the outbreak. In this review, I discuss common conspiracy theories associated with SARS-CoV-2 and Covid-19 and consider how we can address and counterbalance these issues based on scientific information and studies.

摘要

一种新型人类冠状病毒,严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的出现引起了全世界的广泛关注。相关疾病,即 2019 年冠状病毒病(Covid-19),现已涉及全球几乎所有 200 个国家。确诊病例总数远远超过之前两次人类冠状病毒暴发,即严重急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒。随着疫情的升级,有关 SARS-CoV-2 及其相关疾病的虚假信息在全球范围内传播,特别是通过在线和社交媒体传播。阴谋论者相信,病毒没有传染性,是实验室操作的结果,或者是为了通过分发新疫苗来获利而制造的。这种广泛传播的错误信息最危险的影响是,它将对控制疫情的预防措施的态度和行为产生负面影响。在这篇综述中,我讨论了与 SARS-CoV-2 和 Covid-19 相关的常见阴谋论,并考虑了我们如何根据科学信息和研究来解决和应对这些问题。