Effectiveness of the piperine-supplemented L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial.

There is robust evidence of using L. in reducing metabolic levels in people with diabetes. This study analysed the effectiveness of L. in the metabolic control of patients with type 2 diabetes in Brazil. A randomised double-blind placebo-controlled clinical trial was conducted with 71 participants divided into a L. group (500 mg/day with piperine 5 mg) and a placebo group, for 120 days. Anthropometric, clinical and biochemical variables were evaluated at baseline, 60 and 120 days after the beginning of the intervention. Paired and independent Student's -test and chi-square test were used for statistical analysis. The curcuma group presented a significantly decreased glycaemia (=.013), glycated haemoglobin (=.015), HOMA index (=.037) and triglycerides (TGs) (=.002). The use of piperine-added L. was effective in the glycaemic and TG control of patients with type 2 diabetes.