短光开关神经酰胺可实现细胞凋亡的光学控制。
Short Photoswitchable Ceramides Enable Optical Control of Apoptosis.
机构信息
Department of Chemistry, New York University, New York, New York 10003, United States.
Department of Biology/Chemistry, University of Osnabrück, Osnabrück, Germany.
出版信息
ACS Chem Biol. 2021 Mar 19;16(3):452-456. doi: 10.1021/acschembio.0c00823. Epub 2021 Feb 15.
We report short ceramide analogs that can be activated with light and further functionalized using azide-alkyne click chemistry. These molecules, termed , exhibit increased cell permeability compared to their long-chain analogs as demonstrated using mass spectrometry and imaging. Notably, enable optical control of apoptosis, which is not observed with long-chain variants. Additionally, they function as photoswitchable substrates for sphingomyelin synthase 2 (SMS2), exhibiting inverted light-dependence compared to their extended analogs.
我们报告了一些短的神经酰胺类似物，它们可以用光激活，并进一步通过叠氮-炔点击化学进行功能化。这些分子，称为 ，与长链类似物相比，表现出更高的细胞通透性，这一点通过质谱和成像得到了证实。值得注意的是， 能够实现细胞凋亡的光控，而长链变体则没有观察到这种现象。此外，它们还可以作为鞘磷脂合酶 2 (SMS2)的光开关底物，与它们的延伸类似物相比，表现出相反的光依赖性。
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