Mandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC, USA.
Department of Medicine, Clinical Pharmacology Division, Vanderbilt University Medical Center, Nashville, TN, USA.
Physiol Rep. 2021 Feb;9(3):e14678. doi: 10.14814/phy2.14678.
In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β-catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation.
在这篇综述中，我们总结了 Wnt 蛋白在心肌发生中的作用。更具体地说，我们专注于心肌细胞如何从前体细胞发育而来，涉及 Wnt 经典 β-连环蛋白信号通路和涉及 PCP 和 JNK 的 Wnt 非经典信号通路之间的复杂相互作用。我们还描述了最近的文献，表明内源性 Wnt 抑制剂，如 Sfrp 和 DKK 蛋白，在调节心肌细胞分化中发挥重要作用。
