Nyarko Obed O, Sucharov Carmen C
Integrative Physiology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
J Cardiovasc Aging. 2023 Jul;3(3). doi: 10.20517/jca.2023.15. Epub 2023 Jun 9.
Heart failure (HF) is a complex and multifactorial disease. Recent advances have been made in understanding the underlying molecular processes involved in HF pathogenesis. These scientific advancements have brought to light the importance of the secretome. This paper presents a thorough overview of the state of science regarding the secretome's involvement in the onset, progression, and possibility of improved diagnosis and therapeutic interventions in HF. We explore the various types of secreted factors, including novel proteins, growth factors, cytokines, and microRNAs. We also discuss how they affect cellular signaling, angiogenesis, fibrosis, pathological cardiac remodeling, and inflammation in HF. Furthermore, we examine the role of the secretome in cardioprotection and cardiotoxicity. This review emphasizes the potential of the secretome for biomarker discovery. This might enable better HF diagnosis, risk stratification, monitoring and treatment. The review also discusses the difficulties on investigating the role of secreted factors and novel directions on secretome research. It highlights its potential as a target for novel therapeutic approaches and biomarker development.
心力衰竭（HF）是一种复杂的多因素疾病。在理解HF发病机制所涉及的潜在分子过程方面已取得了最新进展。这些科学进展揭示了分泌组的重要性。本文全面概述了关于分泌组参与HF的发病、进展以及改善诊断和治疗干预可能性的科学现状。我们探讨了各种类型的分泌因子，包括新蛋白质、生长因子、细胞因子和微小RNA。我们还讨论了它们如何影响HF中的细胞信号传导、血管生成、纤维化、病理性心脏重塑和炎症。此外，我们研究了分泌组在心脏保护和心脏毒性中的作用。本综述强调了分泌组在生物标志物发现方面的潜力。这可能有助于更好地进行HF诊断、风险分层、监测和治疗。该综述还讨论了研究分泌因子作用的困难以及分泌组研究的新方向。它强调了其作为新型治疗方法靶点和生物标志物开发的潜力。
