低剂量放射治疗对实验性牵引性视网膜脱离的抑制作用。

Suppression of experimental tractional retinal detachment by low-dose radiation therapy.

作者信息

Meredith T A, Ficker L, Stevens R, Olkowski Z, Anderson M, Hartmann J, Crocker I

机构信息

Department of Ophthalmology, Emory University, Atlanta, GA 30322.

出版信息

Arch Ophthalmol. 1988 May;106(5):673-5. doi: 10.1001/archopht.1988.01060130735034.

DOI:10.1001/archopht.1988.01060130735034

PMID:3358735

Abstract

We used a standardized model of traction retinal detachment (TRD) created by cellular membranes in the rabbit to test the effects of low-dose radiation therapy in suppressing TRD. The vitreous and lens were removed from pigmented rabbits, and homologous conjunctival fibroblasts were grown in cell culture. After resolution of postoperative inflammation, 50,000 fibroblasts in 0.1 mL of culture fluid were injected into the vitreous cavity. Ten eyes were maintained as controls. Nineteen eyes received 6 Gy (600 rad) of x-ray irradiation one to three hours after cellular injection. Eyes were monitored weekly for three weeks with indirect ophthalmoscopy. Seven (70%) of ten control eyes developed TRD at one week; no additional TRDs were noted at weeks 2 and 3. Significantly smaller numbers of irradiated eyes developed TRD: at week 1, two (11%) of 19; at week 2, five (28%) of 18; and at week 3, five (29%) of 17.

摘要

我们使用了一种由兔细胞膜构建的标准化牵引性视网膜脱离（TRD）模型，以测试低剂量放射治疗对抑制TRD的效果。从有色兔眼中摘除玻璃体和晶状体，并在细胞培养中培养同源结膜成纤维细胞。术后炎症消退后，将0.1 mL培养液中的50,000个成纤维细胞注入玻璃体腔。十只眼作为对照。19只眼在细胞注射后1至3小时接受6 Gy（600 rad）的X射线照射。每周用间接检眼镜对眼睛进行三周监测。十只对照眼中有七只（70%）在一周时发生TRD；在第2周和第3周未发现其他TRD。接受照射的眼中发生TRD的数量明显较少：在第1周，19只中有两只（11%）；在第2周，18只中有五只（28%）；在第3周，17只中有五只（29%）。