Velikay M, Stolba U, Wedrich A, Datlinger P, Binder S, Handl-Zeller L
1st University Eye Clinic, Vienna, Austria.
Int Ophthalmol. 1993 Aug;17(4):191-3. doi: 10.1007/BF01007739.
Fibroblast injection into the vitreous body causes traction detachment in the rabbit's eye. Various working groups reported different results on the main causes of the development of experimental PVR. These contradictions encouraged us to investigate the main source of experimental PVR by irradiating the ocular tissues before fibroblast implantation thus suppressing cell proliferation originating from host tissue. Over a period of 3 weeks, 22 eyes received ten radiations in a total dosage of 3000 rad. After the last radiation, 250,000 fibroblasts were implanted into 22 eyes. In another 4 eyes, fibroblast implantation but no radiation was carried out. After 8 weeks, 59% of 22 eyes developed different stages of retinal detachment. Comparison with the group of unirradiated eyes, which developed retinal detachment in 85%, revealed no significant differences in the number of detachments.
向兔眼玻璃体腔内注射成纤维细胞会导致视网膜脱离。不同的研究团队就实验性增殖性玻璃体视网膜病变（PVR）发展的主要原因报告了不同的结果。这些矛盾促使我们通过在植入成纤维细胞之前对眼组织进行照射，从而抑制源自宿主组织的细胞增殖，来研究实验性PVR的主要来源。在3周的时间里，22只眼睛接受了10次辐射，总剂量为3000拉德。在最后一次辐射后，将250,000个成纤维细胞植入22只眼睛。另外4只眼睛只进行了成纤维细胞植入但未接受辐射。8周后，22只眼睛中有59%出现了不同阶段的视网膜脱离。与未照射组相比，未照射组视网膜脱离发生率为85%，两组在视网膜脱离数量上没有显著差异。
