Turuvekere Vittala Murthy Namratha, Agrahari Vibhuti, Chauhan Harsh
School of Pharmacy and Health Professionals, Creighton University, Omaha, NE 68178, United States.
Department of Pharmaceutical Sciences, College of Pharmacy, Oklahoma University, Oklahoma City, OK 73117, United States.
Eur J Pharm Biopharm. 2021 Apr;161:66-79. doi: 10.1016/j.ejpb.2021.02.003. Epub 2021 Feb 13.
The emergence of multi-drug resistant (MDR) pathogens has become a global threat and a cause of significant morbidity and mortality around the world. Natural products have been used as a promising approach to counter the infectious diseases associated with these pathogens. The application of natural products and their derivatives especially polyphenolic compounds as antibacterial agents is an active area of research, and prior studies have successfully treated a variety of bacterial infections using these polyphenolic compounds. However, delivery of polyphenolic compounds has been challenging due to their physicochemical properties and often poor aqueous solubility. In this regard, nanotechnology-based novel drug delivery systems offer many advantages, including improving bioavailability and the controlled release of polyphenolic compounds. This review summarizes the pharmacological mechanism and use of nano-formulations in developing controlled release delivery systems of naturally occurring polyphenols in infectious diseases.
多重耐药（MDR）病原体的出现已成为全球威胁，并在世界各地导致大量发病和死亡。天然产物已被用作应对与这些病原体相关的传染病的一种有前景的方法。天然产物及其衍生物尤其是多酚类化合物作为抗菌剂的应用是一个活跃的研究领域，先前的研究已成功使用这些多酚类化合物治疗了多种细菌感染。然而，由于多酚类化合物的物理化学性质以及通常较差的水溶性，其递送一直具有挑战性。在这方面，基于纳米技术的新型药物递送系统具有许多优势，包括提高生物利用度和实现多酚类化合物的控释。本文综述了纳米制剂在开发传染病中天然存在的多酚类化合物控释递送系统中的药理机制和应用。
