Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro, Italy.
Department of Geosciences and CIRCe Centre, University of Padua, Via G. Gradenigo 6, 35129 Padua, Italy.
Int J Mol Sci. 2024 Aug 29;25(17):9363. doi: 10.3390/ijms25179363.
The dispersion of antibiotics in livestock farming represents a health concern worldwide, contributing to the spread of antimicrobial-resistant bacteria through animals, the environment, and humans. Phenolic compounds could be alternatives to antibiotics, once drawbacks such as their low water solubility, bioavailability, and reduced stability are overcome. Although nano- or micro-sized formulations could counter these shortcomings, they do not represent cost-effective options. In this study, three phenolic compounds, obtained from wood-processing manufacturers, were characterized, revealing suitable features such as their antioxidant activity, size, and chemical and colloidal stability for in-field applications. The minimum inhibitory concentration (MIC) of these colloidal suspensions was measured against six bacterial strains isolated from livestock. These particles showed different inhibition behaviors: Colloidal chestnut was effective against one of the most threatening antibiotic-resistant pathogens, i.e., , but ineffective toward . Instead, colloidal pine showed a weak effect on but specificity toward . The present proof-of-concept points at colloidal polyphenols as valuable alternatives for antimicrobial substitutes in the livestock context.
在畜牧业中，抗生素的分散是一个全球性的健康关注点，它导致了抗微生物耐药细菌在动物、环境和人类中的传播。酚类化合物可以作为抗生素的替代品，一旦克服了它们低水溶性、生物利用度和稳定性降低等缺点。虽然纳米或微米级制剂可以克服这些缺点，但它们并不是具有成本效益的选择。在这项研究中，从木材加工制造商获得的三种酚类化合物进行了表征，结果表明其具有合适的特性，如抗氧化活性、尺寸、化学和胶体稳定性，可用于现场应用。这些胶体悬浮液的最小抑菌浓度（MIC）针对从家畜中分离出的六种细菌菌株进行了测量。这些颗粒表现出不同的抑制行为：胶体栗木对一种最具威胁的抗生素耐药病原体有效，即 ，但对 无效。相反，胶体松木对 表现出弱抑制作用，但对 具有特异性。本概念验证表明，胶体多酚在畜牧业中作为抗菌替代品具有很高的应用价值。
