Wang Zetao, Zhong Yanping, He Si, Liang Ruiming, Liao Chuanan, Zheng Li, Zhao Jinmin
Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical Biological Resources Development and Application, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Orthopaedics Trauma and Hand Surgery, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China.
Front Bioeng Biotechnol. 2022 Apr 27;10:859442. doi: 10.3389/fbioe.2022.859442. eCollection 2022.
Electrospinning technology is widely used in the field of drug delivery due to its advantages of convenience, high efficiency, and low cost. To investigate the therapeutic effect of naringenin (Nar) on osteoarthritis (OA), the pH-responsive system of the polycaprolactone/polyethylene glycol-naringenin (PCL/PEG-Nar) nanofiber membrane was designed and used as drug delivery systems (DDS) in the treatment of OA. The PEG-Nar conjugate was constructed via ester linkage between mPEG-COOH and the carboxyl group of naringenin, and the PCL/PEG-Nar nanofiber membrane was prepared by electrospinning technology. When placed in the weak acid OA microenvironment, the PCL/PEG-Nar nanofiber membrane can be cleverly "turned on" to continuously release Nar with anti-inflammatory effect to alleviate the severity of OA. In this study, the construction and the application of the pH-responsive PCL/PEG-Nar nanofiber membrane drug delivery platform would throw new light on OA treatment.
静电纺丝技术因其方便、高效和低成本的优点而在药物递送领域得到广泛应用。为了研究柚皮素（Nar）对骨关节炎（OA）的治疗效果，设计了聚己内酯/聚乙二醇-柚皮素（PCL/PEG-Nar）纳米纤维膜的pH响应系统，并将其用作治疗OA的药物递送系统（DDS）。通过mPEG-COOH与柚皮素的羧基之间的酯键构建PEG-Nar缀合物，并采用静电纺丝技术制备PCL/PEG-Nar纳米纤维膜。当置于弱酸OA微环境中时，PCL/PEG-Nar纳米纤维膜可以巧妙地“开启”，持续释放具有抗炎作用的Nar，以减轻OA的严重程度。在本研究中，pH响应性PCL/PEG-Nar纳米纤维膜药物递送平台的构建和应用将为OA治疗提供新的思路。
