Division of Neonatology Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Center on the Early Life Origins of Disease, Department of Population Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J Perinatol. 2021 May;41(5):1025-1032. doi: 10.1038/s41372-021-00948-4. Epub 2021 Feb 15.
Identify antenatal and neonatal factors associated with primary outcome of EUGR.
1063 preterm infants from a subset of the BBC were included in this prospective cohort study. Regression analysis was carried out to evaluate associations of EUGR with antenatal factors and neonatal factors.
6.1% of the infants had in-utero growth restriction (IUGR) at birth and 21.7% of infants had EUGR. The adjusted odds ratio for EUGR status were significant for birth weight (OR 0.99, p = 0.00, CI 0.99-0.99), for GA at birth (OR 4.58, p = 0.00, CI 3.25-6.44), for PDA (OR 2.9, p = 0.02, CI 1.17-7.1), for NEC (OR 5.14, p = 0.012, CI 1.44-18.3) and for day of life of reaching full feeds (OR 1.04, p = 0.001, CI 1.01-1.06).
This study highlights important factors associated with EUGR. Additional studies are needed to gain further insight.
确定与 EUGR 主要结局相关的产前和新生儿因素。
本前瞻性队列研究纳入了 BBC 子集中的 1063 例早产儿。回归分析用于评估 EUGR 与产前因素和新生儿因素的相关性。
出生时有宫内生长受限（IUGR）的婴儿占 6.1%，有 EUGR 的婴儿占 21.7%。EUGR 状态的调整后比值比在出生体重（OR 0.99，p=0.00，CI 0.99-0.99）、出生时 GA（OR 4.58，p=0.00，CI 3.25-6.44）、PDA（OR 2.9，p=0.02，CI 1.17-7.1）、NEC（OR 5.14，p=0.012，CI 1.44-18.3）和达到全喂养天数（OR 1.04，p=0.001，CI 1.01-1.06）方面具有显著意义。
本研究强调了与 EUGR 相关的重要因素。需要进一步的研究来获得更深入的了解。
