Taams Noor E, Ahmadizar Fariba, Hanewinckel Rens, Drenthen Judith, Voortman Trudy, Ikram M Arfan, Kavousi Maryam, van Doorn Pieter A
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Eur J Neurol. 2021 Jun;28(6):2046-2053. doi: 10.1111/ene.14777. Epub 2021 Mar 12.
Chronic axonal polyneuropathy is a common, usually multifactorial, disease for which there is no treatment yet available. We investigated the association between cardiovascular health, defined by the health score of the American Heart Association, and chronic axonal polyneuropathy.
Between June 2013 and January 2017, we investigated participants of the Rotterdam Study, a population-based cohort study. Participants were screened for polyneuropathy and categorized as having no, possible, probable or definite polyneuropathy. The cardiovascular health score (range 0-14; higher score reflecting better health) consisted of four health behaviours (diet, physical activity, smoking and body mass index) and three health factors (blood pressure, serum cholesterol and fasting glucose level).
We included 1919 participants, of whom 120 (6.3%) had definite polyneuropathy. The median (interquartile range [IQR]) age was 69.0 (58.6-73.7) years and 53.4% were women. A higher cardiovascular health score was associated with a lower prevalence of definite polyneuropathy (per point increase: odds ratio [OR] 0.90, 95% confidence interval [CI] 0.84-0.96). Optimal cardiovascular health (score≥10) was strongly associated with a lower prevalence of definite polyneuropathy (OR 0.55, 95% CI 0.32-0.90). An increase in health factors and health behaviour scores separately was associated with a lower prevalence of polyneuropathy (per point increase: OR 0.82, 95% CI 0.71-0.95 and OR 0.86, 95% CI 0.78-0.96, respectively). The association between a lower cardiovascular health score and lower sural nerve amplitude was not significant after correction for covariates (difference 0.07µV, 95% CI -0.02-0.17).
Better cardiovascular health, consisting of both modifiable health behaviours and health factors, is associated with a lower prevalence of chronic axonal polyneuropathy.
慢性轴索性多发性神经病是一种常见的、通常由多种因素引起的疾病，目前尚无有效的治疗方法。我们研究了由美国心脏协会健康评分定义的心血管健康状况与慢性轴索性多发性神经病之间的关联。
在2013年6月至2017年1月期间，我们对鹿特丹研究的参与者进行了调查，这是一项基于人群的队列研究。对参与者进行多发性神经病筛查，并分类为无、可能、很可能或确诊多发性神经病。心血管健康评分（范围为0 - 14；分数越高反映健康状况越好）由四种健康行为（饮食、体育活动、吸烟和体重指数）和三种健康因素（血压、血清胆固醇和空腹血糖水平）组成。
我们纳入了1919名参与者，其中120人（6.3%）确诊患有多发性神经病。年龄中位数（四分位间距[IQR]）为69.0（58.6 - 73.7）岁，女性占53.4%。较高的心血管健康评分与确诊多发性神经病的较低患病率相关（每增加1分：比值比[OR] 0.90，95%置信区间[CI] 0.84 - 0.96）。最佳心血管健康状况（评分≥10）与确诊多发性神经病的较低患病率密切相关（OR 0.55，95% CI 0.32 - 0.90）。健康因素和健康行为评分分别增加与多发性神经病的较低患病率相关（每增加1分：OR分别为0.82，95% CI 0.71 - 0.95和OR 0.86，95% CI 0.78 - 0.96）。在校正协变量后，较低的心血管健康评分与较低的腓肠神经振幅之间的关联不显著（差异0.07µV，95% CI -0.02 - 0.17）。
更好的心血管健康状况，包括可改变的健康行为和健康因素，与慢性轴索性多发性神经病的较低患病率相关。
