Department of Epidemiology and Health Statistics, the School of Public, Health of Qingdao University, Qingdao, Shandong Province, China.
COPD. 2021 Feb;18(1):101-113. doi: 10.1080/15412555.2021.1884213. Epub 2021 Feb 16.
The association between body mass index (BMI) and chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, a meta-analysis was conducted to further evaluate the relationship. A comprehensive literature search was performed in PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), and Wanfang databases to identify eligible articles until July 15, 2020. Random effect model (REM) was used to compute the pooled results with 95% confidence intervals (CIs). We conducted meta-regression and subgroup analysis to explore potential sources of heterogeneity. Publication bias was evaluated by funnel plots and Egger's test. Thirty articles with 1,578,449 participants were included in the meta-analysis. The pooled OR of COPD was 1.96 (95% CI: 1.78-2.17) for the underweight group, 0.80 (95% CI: 0.73-0.87) for overweight group, and 0.86 (95% CI: 0.73-1.02) for obesity group. After further excluding 5 studies of high between-study heterogeneity in sensitivity analysis, the pooled OR of COPD was 0.77 (95% CI: 0.68-0.86) for the obesity group. This meta-analysis indicated that BMI was associated with COPD. Specifically, underweight might increase the risk of COPD; overweight and obesity might reduce the risk of COPD.
体重指数（BMI）与慢性阻塞性肺疾病（COPD）之间的关系仍存在争议。因此，进行了一项荟萃分析以进一步评估这种关系。在 PubMed、Web of Science、EMBASE、中国国家知识基础设施（CNKI）和万方数据库中进行了全面的文献检索，以确定符合条件的文章，检索时间截至 2020 年 7 月 15 日。使用随机效应模型（REM）计算汇总结果及其 95%置信区间（CI）。我们进行了荟萃回归和亚组分析，以探索潜在的异质性来源。使用漏斗图和 Egger 检验评估发表偏倚。纳入了 30 项研究，共有 1578449 名参与者。对于体重不足组，COPD 的合并 OR 为 1.96（95%CI：1.78-2.17），超重组为 0.80（95%CI：0.73-0.87），肥胖组为 0.86（95%CI：0.73-1.02）。在敏感性分析中进一步排除 5 项研究后，肥胖组的 COPD 的合并 OR 为 0.77（95%CI：0.68-0.86）。这项荟萃分析表明，BMI 与 COPD 有关。具体而言，体重不足可能会增加 COPD 的风险；超重和肥胖可能会降低 COPD 的风险。
