Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, No. 38 Dengzhou Road, Qingdao, 266021, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, No. 175 Shandong Road, Qingdao, 266021, China.
Biol Trace Elem Res. 2020 Apr;194(2):336-347. doi: 10.1007/s12011-019-01803-6. Epub 2019 Jul 12.
The relationship between serum copper (Cu) level and overweight/obesity remains controversial. The purpose of this meta-analysis is to evaluate the relationship. A comprehensive literature search was performed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases for relevant articles until March 20, 2019. The random-effect model (REM) was adopted to compute the combined standardized mean difference (SMD) with 95% confidence interval (CI). Publication bias was estimated using the visualization of funnel plots and Egger's test. In the end, twenty-one articles were included in the meta-analysis. Compared with controls, serum Cu level was higher in obese children (SMD (95% CI) 0.74 (0.16, 1.32)) and in obese adults (SMD (95% CI) 0.39 (0.02, 0.76)). There was no significant difference in serum Cu between overweight and control groups in children (SMD (95% CI) 1.52 (- 0.07, 3.12)) and in adults (SMD (95% CI) 0.16 (- 0.06, 0.38)). Moreover, subgroup analysis revealed a higher serum Cu level in obese children (SMD (95% CI) 0.90 (0.36, 1.45)) and obese adults (SMD (95% CI) 0.47 (0.05, 0.88)) compared with healthy weight controls. The SMD differs significantly between obese children diagnosed by weight-for-height and controls (SMD (95% CI) 1.56 (0.57, 2.55)), and there was a significant difference of serum Cu level between obese adults diagnosed by BMI (WHO) and controls (SMD (95% CI) 0.54 (0.08, 1.01)). This meta-analysis indicates that a higher serum Cu level might be associated with the risk of obesity in children and adults, and these findings need to be further confirmed.
血清铜（Cu）水平与超重/肥胖之间的关系仍存在争议。本荟萃分析旨在评估两者之间的关系。通过检索 PubMed、Web of Science、中国知网（CNKI）和万方数据库，搜集截至 2019 年 3 月 20 日的相关文献，采用随机效应模型（REM）计算合并标准化均数差值（SMD）及其 95%置信区间（CI）。采用漏斗图可视化和 Egger 检验评估发表偏倚。最终纳入 21 篇文献进行荟萃分析。与对照组相比，肥胖儿童的血清 Cu 水平更高（SMD（95%CI）0.74（0.16，1.32）），肥胖成年人的血清 Cu 水平也更高（SMD（95%CI）0.39（0.02，0.76））。儿童（SMD（95%CI）1.52（-0.07，3.12））和成人（SMD（95%CI）0.16（-0.06，0.38））中，超重组与对照组之间的血清 Cu 水平无显著差异。此外，亚组分析显示肥胖儿童（SMD（95%CI）0.90（0.36，1.45））和肥胖成年人（SMD（95%CI）0.47（0.05，0.88））的血清 Cu 水平更高。用体重指数（WHO）诊断的肥胖成年人与对照组之间的血清 Cu 水平差异有统计学意义（SMD（95%CI）0.54（0.08，1.01））。本荟萃分析表明，血清 Cu 水平升高可能与儿童和成人肥胖的发生风险相关，但需要进一步证实。
