Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Org Lett. 2021 Mar 5;23(5):1648-1652. doi: 10.1021/acs.orglett.1c00068. Epub 2021 Feb 16.
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.
本文报道了多边共生体之间发生的分子交换——一种以牙还牙的交换，导致了两种新代谢物的特征描述：conocandin B（真菌来源）和 dentigerumycin F（细菌来源）。结构通过 NMR、质谱、基因组分析和化学衍生化确定。Conocandin B 通过选择性抑制 FabH，表现出对真菌培养蚂蚁的细菌共生体和人类病原菌的抗菌活性，从而破坏脂肪酸生物合成。
