Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.
作者信息
Kirola Laxmi, Budde John P, Wang Fengxian, Norton Joanne, Morris John C, Cruchaga Carlos, Fernández Maria Victoria
机构信息
Department Psychiatry, Washington University School of Medicine (WUSM), 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Hope Center for Neurological Disorders, WUSM, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA.
出版信息
Acta Neuropathol. 2021 Apr;141(4):623-624. doi: 10.1007/s00401-021-02271-w. Epub 2021 Feb 16.
Abstract
摘要
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Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.缺乏证据支持二肽基肽酶6（DPP6）序列变异在欧美人群的阿尔茨海默病中起作用。
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Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.回复：缺乏证据支持二肽基肽酶6（DPP6）序列变异在欧美人群阿尔茨海默病中的作用。
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Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.回复：缺乏证据支持二肽基肽酶6（DPP6）序列变异在欧美人群阿尔茨海默病中的作用。
Acta Neuropathol. 2021 Apr;141(4):625-626. doi: 10.1007/s00401-021-02277-4. Epub 2021 Feb 16.
本文引用的文献
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Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.DPP6 在神经退行性痴呆中的缺失：神经元兴奋性功能障碍的遗传因素。
Acta Neuropathol. 2019 Jun;137(6):901-918. doi: 10.1007/s00401-019-01976-3. Epub 2019 Mar 14.
2
Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease.基于基因的家系方法评估，以检测与家族性晚发型阿尔茨海默病相关的新基因。
Front Neurosci. 2018 Apr 4;12:209. doi: 10.3389/fnins.2018.00209. eCollection 2018.
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DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory.二肽基肽酶6缺失影响海马突触发育，并导致认知、学习和记忆方面的行为障碍。
Front Cell Neurosci. 2018 Mar 29;12:84. doi: 10.3389/fncel.2018.00084. eCollection 2018.
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SORL1 variants across Alzheimer's disease European American cohorts.阿尔茨海默病欧美队列中的SORL1变体
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Second-generation PLINK: rising to the challenge of larger and richer datasets.第二代PLINK：应对更大、更丰富数据集的挑战
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