• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

真菌诱导的巨噬细胞糖酵解通过增强固有淋巴细胞分泌 IL-22 促进结肠癌。

Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22.

机构信息

The State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.

Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

EMBO J. 2021 Jun 1;40(11):e105320. doi: 10.15252/embj.2020105320. Epub 2021 Feb 16.

DOI:10.15252/embj.2020105320
PMID:33591591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8167358/
Abstract

Incorporation of microbiome data has recently become important for prevention, diagnosis, and treatment of colorectal cancer, and several species of bacteria were shown to be associated with carcinogenesis. However, the role of commensal fungi in colon cancer remains poorly understood. Here, we report that mice lacking the c-type lectin Dectin-3 (Dectin-3 ) show increased tumorigenesis and Candida albicans burden upon chemical induction. Elevated C. albicans load triggered glycolysis in macrophages and interleukin-7 (IL-7) secretion. IL-7 induced IL-22 production in RORγt (group 3) innate lymphoid cells (ILC3s) via aryl hydrocarbon receptor and STAT3. Consistently, IL-22 frequency in tumor tissues of colon cancer patients positively correlated with fungal burden, indicating the relevance of this regulatory axis in human disease. These results establish a C. albicans-driven crosstalk between macrophages and innate lymphoid cells in the intestine and expand our understanding on how commensal mycobiota regulate host immunity and promote tumorigenesis.

摘要

微生物组数据的纳入最近对于结直肠癌的预防、诊断和治疗变得重要，并且已经证明几种细菌与癌变有关。然而，共生真菌在结肠癌中的作用仍知之甚少。在这里，我们报告缺乏 C 型凝集素 Dectin-3（Dectin-3）的小鼠在化学诱导下表现出增加的肿瘤发生和白色念珠菌负担。升高的白色念珠菌负荷触发了巨噬细胞中的糖酵解和白细胞介素-7（IL-7）的分泌。IL-7 通过芳香烃受体和 STAT3 诱导 RORγt（第 3 组）固有淋巴细胞（ILC3）中 IL-22 的产生。一致地，结肠癌患者肿瘤组织中 IL-22 的频率与真菌负荷呈正相关，表明该调节轴在人类疾病中的相关性。这些结果确立了肠道中白色念珠菌驱动的巨噬细胞和固有淋巴细胞之间的串扰，并扩展了我们对共生真菌菌群如何调节宿主免疫和促进肿瘤发生的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/9b535572e1fd/EMBJ-40-e105320-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/ba38efce827d/EMBJ-40-e105320-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/8872caa046ca/EMBJ-40-e105320-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/a560388a2bee/EMBJ-40-e105320-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/4616113c90af/EMBJ-40-e105320-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/f009c2ced012/EMBJ-40-e105320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/14f880324e7a/EMBJ-40-e105320-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/6b8b0fc1cd6b/EMBJ-40-e105320-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/09a2f3965265/EMBJ-40-e105320-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/6573b48d664b/EMBJ-40-e105320-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/ae4c7e1f7768/EMBJ-40-e105320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/02585a5d6f8b/EMBJ-40-e105320-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/9b535572e1fd/EMBJ-40-e105320-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/ba38efce827d/EMBJ-40-e105320-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/8872caa046ca/EMBJ-40-e105320-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/a560388a2bee/EMBJ-40-e105320-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/4616113c90af/EMBJ-40-e105320-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/f009c2ced012/EMBJ-40-e105320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/14f880324e7a/EMBJ-40-e105320-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/6b8b0fc1cd6b/EMBJ-40-e105320-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/09a2f3965265/EMBJ-40-e105320-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/6573b48d664b/EMBJ-40-e105320-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/ae4c7e1f7768/EMBJ-40-e105320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/02585a5d6f8b/EMBJ-40-e105320-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c690/8167358/9b535572e1fd/EMBJ-40-e105320-g006.jpg

相似文献

1
Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22.真菌诱导的巨噬细胞糖酵解通过增强固有淋巴细胞分泌 IL-22 促进结肠癌。
EMBO J. 2021 Jun 1;40(11):e105320. doi: 10.15252/embj.2020105320. Epub 2021 Feb 16.
2
Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.RORγt+固有淋巴细胞与肠道巨噬细胞之间的相互作用诱导克罗恩病中黏膜白细胞介素-22的产生。
Inflamm Bowel Dis. 2014 Aug;20(8):1426-34. doi: 10.1097/MIB.0000000000000105.
3
Tryptophan metabolites relieve intestinal infection by altering the gut microbiota to reduce IL-22 release from group 3 innate lymphoid cells of the colon lamina propria.色氨酸代谢物通过改变肠道微生物群来减少结肠固有层 3 型先天淋巴细胞释放的白细胞介素-22，从而缓解肠道感染。
Food Funct. 2024 May 20;15(10):5364-5381. doi: 10.1039/d4fo00432a.
4
Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection.转录因子 STAT3 诱导先天淋巴细胞衍生的白细胞介素-22 介导对肠道感染的保护作用。
Immunity. 2014 Jan 16;40(1):25-39. doi: 10.1016/j.immuni.2013.10.021. Epub 2014 Jan 9.
5
IL-34 Suppresses Candida albicans Induced TNFα Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2.IL-34 通过下调 Dectin-1 和 TLR2 的表达抑制 M1 巨噬细胞中白念珠菌诱导的 TNFα 产生。
J Immunol Res. 2015;2015:328146. doi: 10.1155/2015/328146. Epub 2015 Jun 3.
6
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.Ikaro通过抑制芳烃受体途径来抑制3型天然淋巴细胞的发育和功能。
Immunity. 2016 Jul 19;45(1):185-97. doi: 10.1016/j.immuni.2016.06.027.
7
Vancomycin pre-treatment impairs tissue healing in experimental colitis: Importance of innate lymphoid cells.万古霉素预处理会损害实验性结肠炎中的组织愈合：固有淋巴细胞的重要性。
Biochem Biophys Res Commun. 2017 Jan 29;483(1):237-244. doi: 10.1016/j.bbrc.2016.12.160. Epub 2016 Dec 27.
8
IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis.IL-18 诱导 ILC3 中的 HIF-1α 减轻 C. rodentium 诱导的结肠炎的炎症。
Cell Rep. 2023 Dec 26;42(12):113508. doi: 10.1016/j.celrep.2023.113508. Epub 2023 Nov 28.
9
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.代谢物感应受体 Ffar2 调节结肠固有淋巴细胞亚群 3 和肠道免疫。
Immunity. 2019 Nov 19;51(5):871-884.e6. doi: 10.1016/j.immuni.2019.09.014. Epub 2019 Oct 15.
10
DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation.DOCK8 通过激活 Cdc42 控制肠道中第 3 组固有淋巴细胞的存活。
Int Immunol. 2021 Mar 1;33(3):149-160. doi: 10.1093/intimm/dxaa066.

引用本文的文献

1
The Human Mycobiome: Composition, Immune Interactions, and Impact on Disease.人类真菌微生物组：组成、免疫相互作用及其对疾病的影响。
Int J Mol Sci. 2025 Jul 28;26(15):7281. doi: 10.3390/ijms26157281.
2
The gut microbiota in cancer immunity and immunotherapy.癌症免疫与免疫治疗中的肠道微生物群
Cell Mol Immunol. 2025 Aug 6. doi: 10.1038/s41423-025-01326-2.
3
Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention.聚焦肿瘤相关巨噬细胞与肿瘤微环境之间的相互作用：从机制到干预

本文引用的文献

1
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients.粪便微生物移植可促进免疫治疗耐药性黑色素瘤患者的应答。
Science. 2021 Feb 5;371(6529):602-609. doi: 10.1126/science.abb5920. Epub 2020 Dec 10.
2
Mutational signature in colorectal cancer caused by genotoxic pks E. coli.由基因毒性 pks E. coli 引起的结直肠癌中的突变特征。
Nature. 2020 Apr;580(7802):269-273. doi: 10.1038/s41586-020-2080-8. Epub 2020 Feb 27.
3
Cancer statistics, 2020.癌症统计数据，2020 年。
Theranostics. 2025 Jun 20;15(15):7378-7408. doi: 10.7150/thno.113727. eCollection 2025.
4
Variations in oral health outcomes and mycobiome composition among COVID-19 convalescents.新冠康复者口腔健康结果与微生物组组成的差异。
Sci Rep. 2025 Jul 1;15(1):21638. doi: 10.1038/s41598-025-05078-x.
5
Interaction between Group 3 Innate Lymphoid Cells, Microbiota, and Intestinal Diseases: Mechanisms and Therapeutic Potential.3型固有淋巴细胞、微生物群与肠道疾病之间的相互作用：机制与治疗潜力
J Innate Immun. 2025;17(1):341-353. doi: 10.1159/000546972. Epub 2025 Jun 18.
6
Common mechanisms of Gut microbe-based strategies for the treatment of intestine-related diseases: based on multi-target interactions with the intestinal barrier.基于肠道微生物的肠道相关疾病治疗策略的共同机制：基于与肠道屏障的多靶点相互作用
Cell Commun Signal. 2025 Jun 18;23(1):288. doi: 10.1186/s12964-025-02299-5.
7
Intestinal dysbiosis and colorectal cancer.肠道菌群失调与结直肠癌
Chin Med J (Engl). 2025 Jun 5;138(11):1266-1287. doi: 10.1097/CM9.0000000000003617. Epub 2025 May 19.
8
The role of glycan-lectin interactions in the tumor microenvironment: immunosuppression regulators of colorectal cancer.聚糖-凝集素相互作用在肿瘤微环境中的作用：结直肠癌的免疫抑制调节因子
Am J Cancer Res. 2025 Apr 15;15(4):1347-1383. doi: 10.62347/WBJL4045. eCollection 2025.
9
The power of microbes: the key role of gut microbiota in the initiation and progression of colorectal cancer.微生物的力量：肠道微生物群在结直肠癌发生和发展中的关键作用。
Front Oncol. 2025 Apr 14;15:1563886. doi: 10.3389/fonc.2025.1563886. eCollection 2025.
10
and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling.与结直肠癌：通过代谢物谱分析和预后模型揭示的矛盾作用。
World J Clin Oncol. 2025 Apr 24;16(4):104182. doi: 10.5306/wjco.v16.i4.104182.
CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322/caac.21590. Epub 2020 Jan 8.
4
Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures.结直肠癌相关的微生物群落有助于致癌的表观遗传特征。
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24285-24295. doi: 10.1073/pnas.1912129116. Epub 2019 Nov 11.
5
Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.抗 TNF 疗法通过巨噬细胞 IL-10 信号传导发挥其在 IBD 中的治疗作用。
Gut. 2020 Jun;69(6):1053-1063. doi: 10.1136/gutjnl-2019-318264. Epub 2019 Sep 10.
6
Rerouting metabolism to activate macrophages.重新规划新陈代谢以激活巨噬细胞。
Nat Immunol. 2019 Sep;20(9):1097-1099. doi: 10.1038/s41590-019-0455-5.
7
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD.肠道炎症和消退中的巨噬细胞：IBD 的潜在治疗靶点。
Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):531-543. doi: 10.1038/s41575-019-0172-4. Epub 2019 Jul 16.
8
Differential recognition of , , , and by human innate immune cells.人类先天免疫细胞对[此处原文缺失具体内容，可能是四种物质或因素]、[此处原文缺失具体内容]、[此处原文缺失具体内容]和[此处原文缺失具体内容]的差异识别 。
Infect Drug Resist. 2019 Apr 8;12:783-794. doi: 10.2147/IDR.S197531. eCollection 2019.
9
Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.微生物群诱导的 TNF 样配体 1A 驱动第 3 组先天淋巴细胞介导的屏障保护和结肠炎期间的肠道 T 细胞激活。
Immunity. 2018 Dec 18;49(6):1077-1089.e5. doi: 10.1016/j.immuni.2018.10.014. Epub 2018 Dec 11.
10
Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer.结直肠癌中的肠真菌微生物失调和生态改变。
Gut. 2019 Apr;68(4):654-662. doi: 10.1136/gutjnl-2018-317178. Epub 2018 Nov 24.