人类先天免疫细胞对[此处原文缺失具体内容，可能是四种物质或因素]、[此处原文缺失具体内容]、[此处原文缺失具体内容]和[此处原文缺失具体内容]的差异识别 。
Differential recognition of , , , and by human innate immune cells.
作者信息
Navarro-Arias María J, Hernández-Chávez Marco J, García-Carnero Laura C, Amezcua-Hernández Diana G, Lozoya-Pérez Nancy E, Estrada-Mata Eine, Martínez-Duncker Iván, Franco Bernardo, Mora-Montes Héctor M
机构信息
Department of Biology, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, 36050, Guanajuato, Gto, México,
Laboratory of Human Glycobiology and Molecular Diagnostics, Centro de Investigación en Dinámica Celular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Cuernavaca, 62209, Morelos, México.
出版信息
Infect Drug Resist. 2019 Apr 8;12:783-794. doi: 10.2147/IDR.S197531. eCollection 2019.
BACKGROUND
The deep-seated infections caused by the genus are associated with a high mortality rate, and is the most frequent species associated with these diseases. The fungal wall is composed of macromolecules not synthesized by the host, and therefore is a source of ligands recognized by innate immune cells.
METHODS
We performed a comparative study analyzing the cell wall composition and organization of , , and , along with their ability to stimulate cytokine production and phagocytosis by human innate immune cells.
RESULTS
We found that the wall of these species had the basic components already described in , with most of the chitin and b1,3-glucan located underneath the mannan layer. However, the walls of and were rich in chitin and the former had a lower content of mannans. contained changes in the mannan and the b1,3-glucan levels. These species were differentially phagocytosed by human macrophages and stimulated cytokine production in a dectin-1-dependent pathway. showed the most significant changes in the tested parameters, whereas behaved like .
CONCLUSION
Our results suggest that the cell wall and innate immune recognition of , , , and is different from that reported for .
背景
该属引起的深部感染与高死亡率相关，且是与这些疾病相关的最常见物种。真菌细胞壁由宿主无法合成的大分子组成，因此是天然免疫细胞识别的配体来源。
方法
我们进行了一项比较研究，分析了[具体物种1]、[具体物种2]和[具体物种3]的细胞壁组成和结构，以及它们刺激人类天然免疫细胞产生细胞因子和吞噬作用的能力。
结果
我们发现这些物种的细胞壁具有已在[参考物种]中描述的基本成分，大多数几丁质和β1,3 -葡聚糖位于甘露聚糖层之下。然而，[具体物种1]和[具体物种2]的细胞壁富含几丁质，且前者的甘露聚糖含量较低。[具体物种3]的甘露聚糖和β1,3 -葡聚糖水平发生了变化。这些物种被人类巨噬细胞以不同方式吞噬，并通过依赖于dectin - 1的途径刺激细胞因子产生。[具体物种3]在测试参数中显示出最显著的变化，而[具体物种2]的表现与[参考物种]相似。
结论
我们的结果表明，[具体物种1]、[具体物种2]、[具体物种3]和[参考物种]的细胞壁及天然免疫识别与所报道的[参考物种]不同。
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